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Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

Tanei, Zen-ichi ; Saito, Yuko ; Ito, Shinji ; Matsubara, Tomoyasu ; Motoda, Atsuko ; Yamazaki, Mikihiro ; Sakashita, Yasuhiro ; Kawakami, Ito ; Ikemura, Masako ; Tanaka, Shinya ; Sengoku, Renpei ; Arai, Tomio ; Murayama, Shigeo

Acta neuropathologica, 2021-01, Vol.141 (1), p.25-37 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases
Autor: Tanei, Zen-ichi ; Saito, Yuko ; Ito, Shinji ; Matsubara, Tomoyasu ; Motoda, Atsuko ; Yamazaki, Mikihiro ; Sakashita, Yasuhiro ; Kawakami, Ito ; Ikemura, Masako ; Tanaka, Shinya ; Sengoku, Renpei ; Arai, Tomio ; Murayama, Shigeo
Assuntos: Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; alpha-Synuclein - metabolism ; Analysis ; Autonomic nervous system ; Autopsy ; Axons ; Biological Specimen Banks ; Central nervous system ; Central Nervous System - pathology ; Cohort analysis ; Cohort Studies ; Constipation ; Dementia disorders ; Diagnosis ; Enteric nervous system ; Esophagus ; Esophagus - pathology ; Female ; Humans ; Immunohistochemistry ; Japan ; Lewy bodies ; Lewy Bodies - pathology ; Lewy body disease ; Lewy Body Disease - epidemiology ; Lewy Body Disease - pathology ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Methenamine ; Middle Aged ; Movement disorders ; Myenteric plexus ; Myenteric Plexus - pathology ; Nervous system ; Nervous system diseases ; Neurodegenerative diseases ; Neurophysiology ; Neurosciences ; Original Paper ; Parkinson's disease ; Pathology ; Peripheral Nervous System - pathology ; Prevalence
É parte de: Acta neuropathologica, 2021-01, Vol.141 (1), p.25-37
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clinical diagnoses include Parkinson’s disease (PD), dementia with Lewy bodies, or pure autonomic failure. All types of LBD are accompanied by non-motor symptoms (NMSs) including gastrointestinal dysfunctions such as constipation. Its relationship to Lewy body-related α-synucleinopathy (Lewy pathology) of the enteric nervous system (ENS) is attracting attention because it can precede the motor symptoms. To clarify the role of ENS Lewy pathology in disease progression, we performed a clinicopathological study using the Brain Bank for Aging Research in Japan. Five-hundred and eighteen cases were enrolled in the study. Lewy pathology of the CNS and PNS, including the lower esophagus as a representative of the ENS, was examined via autopsy findings. Results showed that one-third of older people (178 cases, 34%) exhibited Lewy pathology, of which 78 cases (43.8%) exhibited the pathology in the esophagus. In the esophageal wall, Auerbach’s plexus (41.6%) was most susceptible to the pathology, followed by the adventitia (33.1%) and Meissner’s plexus (14.6%). Lewy pathology of the esophagus was significantly associated with autonomic failures such as constipation ( p < 0.0001) and among PNS regions, correlated the most with LBD progression ( r = 0.95, p < 0.05). These findings suggest that the propagation of esophageal Lewy pathology is a predictive factor of LBD.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

Tanei, Zen-ichi ; Saito, Yuko ; Ito, Shinji ; Matsubara, Tomoyasu ; Motoda, Atsuko ; Yamazaki, Mikihiro ; Sakashita, Yasuhiro ; Kawakami, Ito ; Ikemura, Masako ; Tanaka, Shinya ; Sengoku, Renpei ; Arai, Tomio ; Murayama, Shigeo

Berlin/Heidelberg: Springer Berlin Heidelberg

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