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Vasa Vasorum Lumen Narrowing in Brain Vascular Hyalinosis in Systemic Hypertension Patients Who Died of Ischemic Stroke

Gychka, Sergiy G ; Shults, Nataliia V ; Nikolaienko, Sofia I ; Marcocci, Lucia ; Sariipek, Nurefsan E ; Rybka, Vladyslava ; Malysheva, Tatiana A ; Dibrova, Vyacheslav A ; Suzuki, Yuichiro J ; Gavrish, Alexander S

International journal of molecular sciences, 2020-12, Vol.21 (24), p.9611 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Vasa Vasorum Lumen Narrowing in Brain Vascular Hyalinosis in Systemic Hypertension Patients Who Died of Ischemic Stroke
Autor: Gychka, Sergiy G ; Shults, Nataliia V ; Nikolaienko, Sofia I ; Marcocci, Lucia ; Sariipek, Nurefsan E ; Rybka, Vladyslava ; Malysheva, Tatiana A ; Dibrova, Vyacheslav A ; Suzuki, Yuichiro J ; Gavrish, Alexander S
Assuntos: Actin ; Aged ; Aged, 80 and over ; Animals ; Autopsy ; Blood pressure ; brain ; Brain - pathology ; Brain Ischemia - etiology ; Brain Ischemia - mortality ; Brain Ischemia - pathology ; Cells, Cultured ; Clathrin ; Diarrhea - etiology ; Diarrhea - pathology ; Endocytosis ; Endocytosis - genetics ; Endothelial cells ; Endothelial Cells - metabolism ; Endothelium ; Epinephrine ; Eye Diseases, Hereditary - etiology ; Eye Diseases, Hereditary - pathology ; Female ; Gene Knockdown Techniques ; Humans ; hyalinosis ; Hypertension ; Hypertension - complications ; Hypotheses ; Immunohistochemistry ; Intestinal Diseases - etiology ; Intestinal Diseases - pathology ; Ischemia ; ischemic stroke ; Ischemic Stroke - etiology ; Ischemic Stroke - mortality ; Ischemic Stroke - pathology ; Lesions ; Lipid peroxidation ; Lipids ; Male ; Microscopy ; Microvasculature ; Middle Aged ; Nexin ; Oxidative stress ; Oxidative Stress - genetics ; Plasma ; Plasma proteins ; Protein interaction ; Proteins ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; siRNA ; Skin Abnormalities - etiology ; Skin Abnormalities - pathology ; Sorting Nexins - genetics ; Stroke ; Transfection ; Transmission electron microscopy ; vasa vasorum ; Vasa Vasorum - pathology ; vascular ; Vascular Diseases - etiology ; Vascular Diseases - pathology
É parte de: International journal of molecular sciences, 2020-12, Vol.21 (24), p.9611
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Descrição: Ischemic stroke is a major cause of death among patients with systemic hypertension. The narrowing of the lumen of the brain vasculature contributes to the increased incidence of stroke. While hyalinosis represents the major pathological lesions contributing to vascular lumen narrowing and stroke, the pathogenic mechanism of brain vascular hyalinosis has not been well characterized. Thus, the present study examined the postmortem brain vasculature of human patients who died of ischemic stroke due to systemic hypertension. Hematoxylin and eosin staining and immunohistochemistry showed the occurrence of brain vascular hyalinosis with infiltrated plasma proteins along with the narrowing of the vasa vasorum and oxidative stress. Transmission electron microscopy revealed endothelial cell bulge protrusion into the vasa vasorum lumen and the occurrence of endocytosis in the vasa vasorum endothelium. The treatment of cultured microvascular endothelial cells with adrenaline also promoted the formation of the bulge as well as endocytic vesicles. The siRNA knockdown of sortin nexin-9 (a mediator of clathrin-mediated endocytosis) inhibited adrenaline-induced endothelial cell bulge formation. Adrenaline promoted protein-protein interactions between sortin nexin-9 and neural Wiskott-Aldrich syndrome protein (a regulator of actin polymerization). Spontaneously hypertensive stroke-prone rats also exhibited lesions indicative of brain vascular hyalinosis, the endothelial cell protrusion into the lumen of the vasa vasorum, and endocytosis in vasa vasorum endothelial cells. We propose that endocytosis-dependent endothelial cell bulge protrusion narrows the vasa vasorum, resulting in ischemic oxidative damage to cerebral vessels, the formation of hyalinosis, the occurrence of ischemic stroke, and death in systemic hypertension patients.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Vasa Vasorum Lumen Narrowing in Brain Vascular Hyalinosis in Systemic Hypertension Patients Who Died of Ischemic Stroke

Gychka, Sergiy G ; Shults, Nataliia V ; Nikolaienko, Sofia I ; Marcocci, Lucia ; Sariipek, Nurefsan E ; Rybka, Vladyslava ; Malysheva, Tatiana A ; Dibrova, Vyacheslav A ; Suzuki, Yuichiro J ; Gavrish, Alexander S

Switzerland: MDPI AG

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