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Oxygen saturation-dependent effects on blood transverse relaxation at low fields

Thomas, Dion G. ; Galvosas, Petrik ; Tzeng, Yu-Chieh ; Harrison, Freya G. ; Berry, Mary J. ; Teal, Paul D. ; Wright, Graham A. ; Obruchkov, Sergei

Magma (New York, N.Y.), 2022-02, Vol.35 (5), p.805-815 [Periódico revisado por pares]

Cham: Springer International Publishing

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  • Título:
    Oxygen saturation-dependent effects on blood transverse relaxation at low fields
  • Autor: Thomas, Dion G. ; Galvosas, Petrik ; Tzeng, Yu-Chieh ; Harrison, Freya G. ; Berry, Mary J. ; Teal, Paul D. ; Wright, Graham A. ; Obruchkov, Sergei
  • Assuntos: Basic Science - Contrast mechanisms ; Biomedical Engineering and Bioengineering ; Computer Appl. in Life Sciences ; Health Informatics ; Imaging ; Medicine ; Medicine & Public Health ; Radiology ; Research Article ; Solid State Physics
  • É parte de: Magma (New York, N.Y.), 2022-02, Vol.35 (5), p.805-815
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Objective Blood oxygenation can be measured using magnetic resonance using the paramagnetic effect of deoxy-haemoglobin, which decreases the T 2 relaxation time of blood. This T 2 contrast has been well characterised at the B 0 fields used in MRI (1.5 T and above). However, few studies have characterised this effect at lower magnetic fields. Here, the feasibility of blood oximetry at low field based on T 2 changes that are within a physiological relevant range is explored. This study could be used for specifying requirements for construction of a monitoring device based on low field permanent magnet systems. Methods A continuous flow circuit was used to control parameters such as oxygen saturation and temperature in a sample of blood. It flowed through a variable field magnet, where CPMG experiments were performed to measure its T 2 . In addition, the oxygen saturation was monitored by an optical sensor for comparison with the T 2 changes. Results These results show that at low B 0 fields, the change in blood T 2 due to oxygenation is small, but still detectable. The data measured at low fields are also in agreement with theoretical models for the oxy-deoxy T 2 effect. Conclusion T 2 changes in blood due to oxygenation were observed at fields as low as 0.1 T. These results suggest that low field NMR relaxometry devices around 0.3 T could be designed to detect changes in blood oxygenation.
  • Editor: Cham: Springer International Publishing
  • Idioma: Inglês
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