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Survival Mechanisms of Bacterial Pathogens

Singh, Yogendra

Indian journal of clinical biochemistry, 2022-05, Vol.29 (S1), p.S27 [Periódico revisado por pares]

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Título:
Survival Mechanisms of Bacterial Pathogens
Autor: Singh, Yogendra
Assuntos: Health aspects ; Pathogenic microorganisms ; Tuberculosis
É parte de: Indian journal of clinical biochemistry, 2022-05, Vol.29 (S1), p.S27
Descrição: Human immune system is capable of fighting most of the pathogens that they encounter throughout their lives. However, several pathogens have the ability to infect the host and establish diseases by modifying the host defence mechanisms, particularly during the initial phases of the infection. Tuberculosis, caused by Mycobacterium tuberculosis, is a major global health problem. According to WHO report, tuberculosis takes one life every 22 seconds. Tuberculosis is treated with a combination of four drugs. In the last two decades, multidrug resistant strains of M. tuberculosis have emerged. The condition has become graver because no new TB drug has been introduced in the last five decades. M. tuberculosis has a myriad of proteins involved in the subversion of our immune system. Similarly, another less known spore forming pathogen is Bacillus anthracis which causes anthrax. This pathogen has the ability to subvert the phagocytosis by macrophages which helps in disease establishment. Our efforts are towards understanding the signalling pathways of these pathogens and mechanisms by which they manage to survive in the host.
Editor: Springer
Idioma: Inglês

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