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Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

Kreps, Lauren M ; Addison, Christina L

International journal of molecular sciences, 2021-03, Vol.22 (6), p.2911 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth
Autor: Kreps, Lauren M ; Addison, Christina L
Assuntos: Adipocytes ; Angiogenesis ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Bone and Bones - drug effects ; Bone and Bones - immunology ; Bone and Bones - pathology ; Bone growth ; Bone marrow ; Bone mass ; bone metastasis ; Bone Neoplasms - genetics ; Bone Neoplasms - immunology ; Bone Neoplasms - pathology ; Bone Neoplasms - prevention & control ; Bone remodeling ; Bone tumors ; Breast ; Breast cancer ; Cancer therapies ; Cell Communication ; Cell cycle ; Cell growth ; Cell interactions ; Cell signaling ; Chemotherapy ; Clinical outcomes ; Cytokines - genetics ; Cytokines - metabolism ; Dormancy ; Extravasation ; Fractures ; Gene Expression Regulation, Neoplastic ; Growth factors ; Humans ; Hypoxia ; immunosuppression ; Lung cancer ; Lymphatic Metastasis ; Macrophages - drug effects ; Macrophages - immunology ; Macrophages - pathology ; Medical prognosis ; Metastases ; Metastasis ; Microenvironments ; Myeloid-Derived Suppressor Cells - drug effects ; Myeloid-Derived Suppressor Cells - immunology ; Myeloid-Derived Suppressor Cells - pathology ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - immunology ; Neovascularization, Pathologic - pathology ; Neovascularization, Pathologic - prevention & control ; Osteoblasts - drug effects ; Osteoblasts - immunology ; Osteoblasts - pathology ; osteoclast ; Osteoclasts - drug effects ; Osteoclasts - immunology ; Osteoclasts - pathology ; Pain ; Patients ; Prostate ; Prostate cancer ; Review ; Signal Transduction ; Stem cells ; Thyroid ; Tumor cells ; Tumor Escape - drug effects ; Tumor Escape - genetics ; Tumor Microenvironment - drug effects ; Tumor Microenvironment - genetics ; Tumor Microenvironment - immunology ; Tumors ; Vascular Endothelial Growth Factors - antagonists & inhibitors ; Vascular Endothelial Growth Factors - genetics ; Vascular Endothelial Growth Factors - metabolism
É parte de: International journal of molecular sciences, 2021-03, Vol.22 (6), p.2911
Descrição: Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a complex process involving not only intravasation of tumor cells from the primary tumor into circulation, but extravasation from circulation into the bone where they meet an environment that is generally suppressive of their growth. The bone microenvironment can inhibit the growth of disseminated tumor cells (DTC) by inducing dormancy of the DTC directly and later on following formation of a micrometastatic tumour mass by inhibiting metastatic processes including angiogenesis, bone remodeling and immunosuppressive cell functions. In this review we will highlight some of the mechanisms mediating DTC dormancy and the complex relationships which occur between tumor cells and bone resident cells in the bone metastatic microenvironment. These inter-cellular interactions may be important targets to consider for development of novel effective therapies for the prevention or treatment of bone metastases.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

Kreps, Lauren M ; Addison, Christina L

Switzerland: MDPI AG

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