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Detection of 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain in pyronaridine-resistant P berghei ANKA strain

Li, G D ; Liu, S Q ; Ye, X Y ; Qu, F Y

Zhōngguó yàoli xuébào, 1995, Vol.16 (1), p.17-20 [Periódico revisado por pares]

Beijing: Science Press

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Título:
Detection of 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain in pyronaridine-resistant P berghei ANKA strain
Autor: Li, G D ; Liu, S Q ; Ye, X Y ; Qu, F Y
Assuntos: Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimalarials - pharmacology ; Antiparasitic agents ; Biological and medical sciences ; Chloroquine - pharmacology ; Drug Resistance ; Immunoblotting ; Medical sciences ; Mice ; Microscopy, Immunoelectron ; Naphthyridines - pharmacology ; Pharmacology. Drug treatments ; Plasmodium berghei - chemistry ; Plasmodium berghei - drug effects ; Plasmodium berghei - ultrastructure ; Protozoan Proteins - analysis
É parte de: Zhōngguó yàoli xuébào, 1995, Vol.16 (1), p.17-20
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A 54-kDa protein overexpressed by chloroquine-resistant (CR) Plasmodium berghei ANKA strain was first reported by us. This study is conducted to detect the protein in pyronaridine-resistant (PR) P berghei ANKA strain. Immunoblotting analysis and immunoelectron microscopy were used. PR parasites, like CR parasites, mainly overexpressed 2 major bands of 37 (36-38) kDa and 16 (15-17) kDa which were considered to be 2 subunits of 54 (52-62) kDa protein. Three of 7 times of experiments showed a 54-kDa and a 96 (95-100) kDa bands. The proteins were localized to be mainly scattered in cytoplasm of trophozoites, schizonts, and merozoites of erythrocytic stage of P berghei. Some of them were distributed in cytoplasm of erythrocytes infected with parasites. Both PR and CR parasites overexpressed the same proteins.
Editor: Beijing: Science Press
Idioma: Inglês

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Detection of 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain in pyronaridine-resistant P berghei ANKA strain

Li, G D ; Liu, S Q ; Ye, X Y ; Qu, F Y

Beijing: Science Press

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