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Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice

Jurado-Ruiz, Enrique ; Álvarez-Amor, Leticia ; Varela, Lourdes M ; Berná, Genoveva ; Parra-Camacho, María S ; Oliveras-Lopez, María J ; Martínez-Force, Enrique ; Rojas, Anabel ; Hmadcha, Abdelkrim ; Soria, Bernat ; Martín, Franz

Scientific reports, 2019-08, Vol.9 (1), p.11311-13, Article 11311 [Periódico revisado por pares]

England: Nature Publishing Group

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Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice
Autor: Jurado-Ruiz, Enrique ; Álvarez-Amor, Leticia ; Varela, Lourdes M ; Berná, Genoveva ; Parra-Camacho, María S ; Oliveras-Lopez, María J ; Martínez-Force, Enrique ; Rojas, Anabel ; Hmadcha, Abdelkrim ; Soria, Bernat ; Martín, Franz
Assuntos: Animal models ; Animals ; Apoptosis ; Blood glucose ; Blood Glucose - metabolism ; Cell number ; Cells, Cultured ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - diet therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diet ; Diet, High-Fat - methods ; Disease Models, Animal ; Glucose ; Glucose - metabolism ; Glucose tolerance ; High fat diet ; Homeostasis ; Insulin ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; Insulin-Secreting Cells - metabolism ; Male ; Mice, Inbred C57BL ; Olive oil ; Olive Oil - therapeutic use ; Pancreas ; Phenolic compounds ; Secretion
É parte de: Scientific reports, 2019-08, Vol.9 (1), p.11311-13, Article 11311
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether an extra virgin olive oil (EVOO) high fat diet (HFD) can improve glucose homeostasis. C57BL/6J mice were fed a standard diet or a lard-based HFD to induce type 2 diabetes. Then, HFD mice were fed with three different based HFD (lard, EVOO and EVOO rich in phenolic compounds) for 24 weeks. HFD-EVOO diets significantly improved glycemia, insulinemia, glucose tolerance, insulin sensitivity and insulin degradation. Moreover, EVOO diets reduced β-cell apoptosis, increased β-cell number and normalized islet glucose metabolism and glucose induced insulin secretion. No additional effects were observed by higher levels of phenolic compounds. Thus, EVOO intake regulated glucose homeostasis by improving insulin sensitivity and pancreatic β-cell function, in a type 2 diabetes HFD animal model.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice

Jurado-Ruiz, Enrique ; Álvarez-Amor, Leticia ; Varela, Lourdes M ; Berná, Genoveva ; Parra-Camacho, María S ; Oliveras-Lopez, María J ; Martínez-Force, Enrique ; Rojas, Anabel ; Hmadcha, Abdelkrim ; Soria, Bernat ; Martín, Franz

England: Nature Publishing Group

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