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Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by ^sup 18^F-FDG PET

Benz, Matthias R ; Dry, Sarah M ; Eilber, Fritz C ; Allen-Auerbach, Martin S ; Tap, William D ; Elashoff, David ; Phelps, Michael E ; Czernin, Johannes

The Journal of nuclear medicine (1978), 2010-08, Vol.51 (8), p.1174 [Periódico revisado por pares]

New York: Society of Nuclear Medicine

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  • Título:
    Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by ^sup 18^F-FDG PET
  • Autor: Benz, Matthias R ; Dry, Sarah M ; Eilber, Fritz C ; Allen-Auerbach, Martin S ; Tap, William D ; Elashoff, David ; Phelps, Michael E ; Czernin, Johannes
  • Assuntos: Biopsy ; Genotype & phenotype ; Radiation therapy ; Review boards ; Studies
  • É parte de: The Journal of nuclear medicine (1978), 2010-08, Vol.51 (8), p.1174
  • Descrição: Tumor glycolytic phenotyping can be accomplished with ^sup 18^F-FDG PET. Tumor ^sup 18^F-FDG uptake correlates with tumor grade in several cancers. However, the role of ^sup 18^F-FDG PET for the grading of soft-tissue sarcomas (STSs) warrants further research. Methods: One hundred two patients (48 men and 54 women; mean age ± SD, 50 ± 17 y) with 12 STS subtypes underwent ^sup 18^F-FDG PET/CT before treatment. Tumor ^sup 18^F-FDG uptake, expressed as maximum standardized uptake value (SUVmax), was compared among subtypes and correlated with histopathologic grade. Two frequently used sarcoma grading systems-the 3-tier system of the French Federation of Cancer Centers Sarcoma Group (Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC]) and a 2-tier system (low grade vs. high grade)-were used. Results: More than 90% of STSs (93/102) exhibited a strong glycolytic phenotype (SUVmax, 2.7-52.2 g/mL). Tumor SUVmax differed significantly among tumor grades (P < 0.001 for the 3- and 2-tier grading systems). The FNCLCC and 2-tier grading systems predicted tumor grade with similar accuracy (area under the curve, 0.83 and 0.85, respectively; P = 0.35). SUVmax differed significantly among histologic subtypes (P = 0.03) in the entire population but not when high-grade STSs were analyzed separately (P = 0.31). Conclusion: The tumor glycolytic phenotype correlated significantly with histologic grade as determined by both the FNCLCC and 2-tier (high vs. low) grading systems. ^sup 18^F-FDG PET cannot be used to reliably distinguish among grade 2 and 3 STSs (by FNCLCC) and the various subtypes. [PUBLICATION ABSTRACT]
  • Editor: New York: Society of Nuclear Medicine
  • Idioma: Inglês
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