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Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine

Weber, Michael ; Hamm, Christian

Heart (British Cardiac Society), 2006-06, Vol.92 (6), p.843-849 [Periódico revisado por pares]

London: BMJ Publishing Group Ltd and British Cardiovascular Society

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Título:
Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine
Autor: Weber, Michael ; Hamm, Christian
Assuntos: Acute coronary syndromes ; Automation ; B-type natriuretic peptide ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; BNP ; Cardiology. Vascular system ; Cardiovascular disease ; coronary artery disease ; Coronary Artery Disease - diagnosis ; Coronary vessels ; Education in Heart ; Emergency medical care ; Emergency Treatment ; Gene expression ; Heart attacks ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - therapy ; Heart Valve Diseases - diagnosis ; Humans ; Medical sciences ; Natriuretic Peptide, Brain - blood ; Nervous system ; NT-proBNP ; Peptide Fragments - blood ; Peptides ; Physiology ; Prognosis ; Rodents ; Task forces
É parte de: Heart (British Cardiac Society), 2006-06, Vol.92 (6), p.843-849
Notas: Correspondence to:  Michael Weber  MD, Kerckhoff Heart Center, Department of Cardiology, Benekestraße 2–8, 61231 Bad Nauheim, Germany; M.Weber@kerckhoff-klinik.de
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Descrição: NT-proBNP seems to be affected more by worsening renal function than BNP. Besides diminished renal clearance, higher prevalence of concomitant left ventricular alterations such as left ventricular hypertrophy, diastolic and systolic dysfunction as well as fluid overload might contribute to elevated BNP and NT-proBNP concentrations. Role of BNP and NT-proBNP in clinical routine: key points B-type natriuretic peptide (BNP) and NT-proBNP are reliable biomarkers, reflecting myocardial stress caused by various cardiovascular diseases Both markers are stable in whole blood and can be measured in clinical routine using fully automated commercially available assays The diagnostic performance of BNP and NT-proBNP is comparable and there is no meaningful difference between the two The particular strength of BNP and NT-proBNP is to rule out heart failure in patients with shortness of breath in the emergency department Both markers provide prognostic information in patients with heart failure, coronary artery disease, and valvular heart disease Additional references appear on the Heart website- http://www.heartjnl.com/supplemental
Editor: London: BMJ Publishing Group Ltd and British Cardiovascular Society
Idioma: Inglês

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Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine

Weber, Michael ; Hamm, Christian

London: BMJ Publishing Group Ltd and British Cardiovascular Society

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