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Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis

Beghini, Joziani ; Giraldo, Paulo C. ; Linhares, Iara M. ; Ledger, William J. ; Witkin, Steven S.

Reproductive sciences (Thousand Oaks, Calif.), 2015-08, Vol.22 (8), p.964-968 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

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Título:
Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis
Autor: Beghini, Joziani ; Giraldo, Paulo C. ; Linhares, Iara M. ; Ledger, William J. ; Witkin, Steven S.
Assuntos: Acute-Phase Proteins - analysis ; Adult ; Biomarkers - analysis ; Body Fluids - chemistry ; Body Fluids - microbiology ; Body Fluids - secretion ; Candidiasis, Vulvovaginal - diagnosis ; Candidiasis, Vulvovaginal - immunology ; Candidiasis, Vulvovaginal - metabolism ; Candidiasis, Vulvovaginal - microbiology ; Case-Control Studies ; Down-Regulation ; Embryology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunity, Innate ; Lactic Acid - analysis ; Lipocalin-2 ; Lipocalins - analysis ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Original Article ; Proto-Oncogene Proteins - analysis ; Reproductive Medicine ; Vagina - immunology ; Vagina - metabolism ; Vagina - microbiology ; Vagina - secretion ; Vaginosis, Bacterial - diagnosis ; Vaginosis, Bacterial - immunology ; Vaginosis, Bacterial - metabolism ; Vaginosis, Bacterial - microbiology ; Young Adult
É parte de: Reproductive sciences (Thousand Oaks, Calif.), 2015-08, Vol.22 (8), p.964-968
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SourceType-Scholarly Journals-1
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Descrição: Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is a component of innate immunity that prevents iron uptake by microorganisms. We evaluated whether NGAL was present in vaginal fluid and whether concentrations were altered in women with bacterial vaginosis (BV) or vulvovaginal candidiasis (VVC). Methods: Vaginal secretions from 52 women with VVC, 43 with BV, and 77 healthy controls were assayed by enzyme-linked immunosorbent assay for NGAL and for concentrations of l-lactic acid. Results: The median concentration of NGAL in vaginal fluid was significantly higher in control women (561 pg/mL) than in women with BV (402 pg/mL; P = .0116) and lower in women with VVC (741 pg/mL; P = .0017). Median lactic acid levels were similar in controls (0.11 mmol/L) and women with VVC (0.13 mmol/L) and were lower in women with BV (0.02 mmol/L; P < .0001). The NGAL and lactic acid concentrations were highly correlated (P < .0001). Conclusion: A decrease in Lactobacilli and/or lactic acid plus the absence of leukocytes results in lower vaginal NGAL levels that might facilitate the growth of bacteria associated with BV.
Editor: Los Angeles, CA: SAGE Publications
Idioma: Inglês

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Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid: Relation to Bacterial Vaginosis and Vulvovaginal Candidiasis

Beghini, Joziani ; Giraldo, Paulo C. ; Linhares, Iara M. ; Ledger, William J. ; Witkin, Steven S.

Los Angeles, CA: SAGE Publications

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