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Evaluation of olfactory dysfunction in neurodegenerative diseases

Barresi, Marina ; Ciurleo, Rosella ; Giacoppo, Sabrina ; Foti Cuzzola, Valeria ; Celi, Debora ; Bramanti, Placido ; Marino, Silvia

Journal of the neurological sciences, 2012-12, Vol.323 (1), p.16-24 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Evaluation of olfactory dysfunction in neurodegenerative diseases
Autor: Barresi, Marina ; Ciurleo, Rosella ; Giacoppo, Sabrina ; Foti Cuzzola, Valeria ; Celi, Debora ; Bramanti, Placido ; Marino, Silvia
Assuntos: Aging - physiology ; Alzheimer Disease - complications ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Discrimination (Psychology) ; Evoked Potentials ; Functional magnetic resonance imaging ; Humans ; Huntington Disease - complications ; Huntington Disease - physiopathology ; Huntington's disease ; Magnetic Resonance Imaging ; Medical sciences ; Motor neuron disease ; Motor Neuron Disease - complications ; Motor Neuron Disease - physiopathology ; Multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - physiopathology ; Neurodegenerative Diseases - complications ; Neurodegenerative Diseases - physiopathology ; Neurology ; Neuropsychological Tests ; Odorants ; Olfaction Disorders - diagnosis ; Olfaction Disorders - etiology ; Olfaction Disorders - physiopathology ; Olfactory dysfunction ; Olfactory event-related potentials ; Olfactory Pathways - physiopathology ; Parkinson Disease - complications ; Parkinson Disease - physiopathology ; Parkinson's disease ; Sensory Thresholds
É parte de: Journal of the neurological sciences, 2012-12, Vol.323 (1), p.16-24
Notas: ObjectType-Article-2
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Descrição: Abstract It is known that the olfactory dysfunction is involved in various neurological diseases, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, Huntington's disease and motor neuron disease. In particular, the ability to identify and discriminate the odors, as well as the odor threshold, can be altered in these disorders. These changes often occur as early manifestation of the pathology and they are not always diagnosed on time. The aim of this review is to summarize the major neurological diseases which are preceded or accompanied by olfactory dysfunction. In addition, new instrumental approaches, such as psychophysical testing, olfactory event-related potentials (OERPs) and functional magnetic resonance imaging (fMRI) measurements, supported by olfactometer for the stimuli delivery, and their combination in evaluation of olfactory function will be discussed. In particular, OERPs and fMRI might to be good candidates to become useful additional tools in clinical protocols for early diagnosis of neurological diseases.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Evaluation of olfactory dysfunction in neurodegenerative diseases

Barresi, Marina ; Ciurleo, Rosella ; Giacoppo, Sabrina ; Foti Cuzzola, Valeria ; Celi, Debora ; Bramanti, Placido ; Marino, Silvia

Amsterdam: Elsevier B.V

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