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Ventilation defect formation in healthy and asthma subjects is determined by lung inflation

Harris, R Scott ; Fujii-Rios, Hanae ; Winkler, Tilo ; Musch, Guido ; Vidal Melo, Marcos F ; Venegas, José G Idzko, Marco

PloS one, 2012-12, Vol.7 (12), p.e53216-e53216 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Ventilation defect formation in healthy and asthma subjects is determined by lung inflation
Autor: Harris, R Scott ; Fujii-Rios, Hanae ; Winkler, Tilo ; Musch, Guido ; Vidal Melo, Marcos F ; Venegas, José G
Idzko, Marco
Assuntos: Adult ; Asthma ; Asthma - physiopathology ; Bronchoconstriction ; Bronchoconstriction - physiology ; Case-Control Studies ; Chemistry ; Consent ; Critical care ; Defects ; Drug dosages ; Edema ; Emission measurements ; Female ; Hospitals ; Humans ; Inflation ; Inflation (Economics) ; Inflation (Finance) ; Intravenous administration ; Lung - diagnostic imaging ; Lung - pathology ; Lungs ; Male ; Medical imaging ; Medical schools ; Medicine ; Methacholine ; Middle Aged ; Muscles ; Positron emission ; Positron emission tomography ; Pulmonary Gas Exchange ; Pulmonary Ventilation - physiology ; Radiography ; Respiration ; Smooth muscle ; Spirometry ; Stress concentration ; Ventilation ; Ventilators ; Washout ; Young Adult
É parte de: PloS one, 2012-12, Vol.7 (12), p.e53216-e53216
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: RSH JGV. Performed the experiments: RSH TW GM MFVM JGV. Analyzed the data: RSH TW GM MFVM JGV. Wrote the paper: RSH HFR TW GM MFVM JGV.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Imaging studies have demonstrated that ventilation during bronchoconstriction in subjects with asthma is patchy with large ventilation defective areas (Vdefs). Based on a theoretical model, we postulated that during bronchoconstriction, as smooth muscle force activation increases, a patchy distribution of ventilation should emerge, even in the presence of minimal heterogeneity the lung. We therefore theorized that in normal lungs, Vdefs should also emerge in regions of the lung with reduced expansion. We studied 12 healthy subjects to evaluate whether Vdefs formed during bronchoconstriction, and compared their Vdefs with those observed in 9 subjects with mild asthma. Spirometry, low frequency (0.15 Hz) lung elastance and resistance, and regional ventilation by intravenous ¹³NN-saline positron emission tomography were measured before and after a challenge with nebulized methacholine. Vdefs were defined as regions with elevated residual ¹³NN after a period of washout. The average location, ventilation, volume, and fractional gas content of the Vdefs, relative to those of the rest of the lung, were calculated for both groups. Consistent with the predictions of the theoretical model, both healthy subjects and those with asthma developed Vdefs. These Vdefs tended to form in regions that, at baseline, had a lower degree of lung inflation and, in healthy subjects, tended to occur in more dependent locations than in subjects with asthma. The formation of Vdefs is determined by the state of inflation prior to bronchoconstriction.
Editor: United States: Public Library of Science
Idioma: Inglês

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Ventilation defect formation in healthy and asthma subjects is determined by lung inflation

Harris, R Scott ; Fujii-Rios, Hanae ; Winkler, Tilo ; Musch, Guido ; Vidal Melo, Marcos F ; Venegas, José G Idzko, Marco

United States: Public Library of Science

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