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Primary plasma cell leukemia: Report of 17 new cases treated with autologous or allogeneic stem‐cell transplantation and review of the literature

Saccaro, Steven ; Fonseca, Rafael ; Veillon, Diana M. ; Cotelingam, James ; Nordberg, Mary L. ; Bredeson, Christopher ; Glass, Jonathan ; Munker, Reinhold

American journal of hematology, 2005-04, Vol.78 (4), p.288-294 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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  • Título:
    Primary plasma cell leukemia: Report of 17 new cases treated with autologous or allogeneic stem‐cell transplantation and review of the literature
  • Autor: Saccaro, Steven ; Fonseca, Rafael ; Veillon, Diana M. ; Cotelingam, James ; Nordberg, Mary L. ; Bredeson, Christopher ; Glass, Jonathan ; Munker, Reinhold
  • Assuntos: Adult ; Humans ; Leukemia, Plasma Cell - therapy ; Male ; Middle Aged ; plasma cell leukemia ; Prognosis ; Stem Cell Transplantation ; Transplantation, Autologous ; Transplantation, Homologous ; Treatment Outcome
  • É parte de: American journal of hematology, 2005-04, Vol.78 (4), p.288-294
  • Notas: ObjectType-Case Study-3
    SourceType-Scholarly Journals-1
    content type line 23
    ObjectType-Review-1
    ObjectType-Feature-5
    ObjectType-Report-2
    ObjectType-Article-4
  • Descrição: Primary plasma cell leukemia (PPCL) is a rare hematologic malignancy characterized by the proliferation of plasma cells in blood, bone marrow, and other organs in the absence of established multiple myeloma. PPCL has a poor prognosis when treated with conventional therapy for multiple myeloma. We describe here 17 new cases of PPCL who underwent stem‐cell transplantation (SCT) (2 cases observed by the authors and 15 cases from the International Bone Marrow Transplant Registry [IBMTR]). The first case was diagnosed in a 21‐year‐old male who presented with leukocytosis and acute renal failure. He was treated with hyper‐CVAD, entered complete remission, and then proceeded to high‐dose chemotherapy with peripheral stem‐cell support. He is currently in complete remission 23 months after initial diagnosis and 19 months after autologous SCT. The second case was observed in a 31‐year‐old male who presented with leukocytosis and hepatic infiltration with plasma cells. He was treated with VAD chemotherapy and underwent allogeneic bone marrow transplantation from his HLA‐identical sister. He remained in complete remission for 3 years and then developed progressive refractory disease, dying 7 years after the initial diagnosis. In addition to these 2 cases, 15 further unpublished cases of PPCL from the IBMTR are reported here (treated between 1993 and 2001, 6 by autologous and 9 by allogeneic transplantation). Finally, the features of PPCL, the outcome, published data of SCT for PPCL, and indications for treatment are discussed. Am. J. Hematol. 78:288–294, 2005. © 2005 Wiley‐Liss, Inc.
  • Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
  • Idioma: Inglês
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