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B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

Azuma, Takeshi ; Yao, Sheng ; Zhu, Gefeng ; Flies, Andrew S. ; Flies, Sarah J. ; Chen, Lieping

Blood, 2008-04, Vol.111 (7), p.3635-3643 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
Autor: Azuma, Takeshi ; Yao, Sheng ; Zhu, Gefeng ; Flies, Andrew S. ; Flies, Sarah J. ; Chen, Lieping
Assuntos: Animals ; Antigens, Surface - immunology ; Antineoplastic agents ; Apoptosis - drug effects ; Apoptosis - immunology ; Apoptosis Regulatory Proteins - immunology ; B7-1 Antigen - immunology ; B7-H1 Antigen ; Biological and medical sciences ; Cell Line, Tumor ; Enzyme Inhibitors - pharmacology ; fas Receptor - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Humans ; Immunity, Cellular - drug effects ; Immunity, Cellular - immunology ; Immunobiology ; Medical sciences ; Membrane Glycoproteins - immunology ; Mice ; Mice, Inbred DBA ; Modulation of the immune response (stimulation, suppression) ; Neoplasms - immunology ; Neoplasms - pathology ; Peptides - immunology ; Pharmacology. Drug treatments ; Programmed Cell Death 1 Receptor ; Signal Transduction - drug effects ; Signal Transduction - immunology ; Staurosporine - pharmacology ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology
É parte de: Blood, 2008-04, Vol.111 (7), p.3635-3643
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Descrição: B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers, and its functions have been attributed to delivering an inhibitory signal to its counter-receptor programmed death-1 (PD-1) on T cells. Here we report that B7-H1 on cancer cells receives a signal from PD-1 to rapidly induce resistance against T cell–mediated killing because crippling signaling capacity of B7-H1 but not PD-1 ablates this resistance. Importantly, loss of B7-H1 signaling is accompanied by increased susceptibility to immune-mediated tumoricidal activity. In addition to resistance against T-cell destruction, B7-H1+ cancer cells also become refractory to apoptosis induced by Fas ligation or the protein kinase inhibitor Staurosporine. Our study reveals a new mechanism by which cancer cells use a receptor on immune cells as a ligand to induce resistance to therapy.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

Azuma, Takeshi ; Yao, Sheng ; Zhu, Gefeng ; Flies, Andrew S. ; Flies, Sarah J. ; Chen, Lieping

Washington, DC: Elsevier Inc

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