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Levetiracetam Rectal Administration in Healthy Dogs

Peters, R.K ; Schubert, T ; Clemmons, R ; Vickroy, T

Journal of veterinary internal medicine, 2014-03, Vol.28 (2), p.504-509 [Peer Reviewed Journal]

United States: J.B. Lippincott

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Title:
Levetiracetam Rectal Administration in Healthy Dogs
Author: Peters, R.K ; Schubert, T ; Clemmons, R ; Vickroy, T
Subjects: Administration, Rectal ; adverse effects ; Animals ; Anticonvulsant ; Anticonvulsants - administration & dosage ; Anticonvulsants - blood ; Anticonvulsants - pharmacokinetics ; Anticonvulsants - therapeutic use ; blood serum ; clinical trials ; Cluster ; Convulsions & seizures ; diazepam ; Dog Diseases - drug therapy ; Dogs ; Epilepsy ; Epilepsy - drug therapy ; Epilepsy - veterinary ; feces ; Female ; humans ; Male ; medicine ; Original ; Pharmacokinetics ; Piracetam - administration & dosage ; Piracetam - analogs & derivatives ; Piracetam - blood ; Piracetam - pharmacokinetics ; Piracetam - therapeutic use ; rectum ; Risk factors ; sedation ; seizures ; Status
Is Part Of: Journal of veterinary internal medicine, 2014-03, Vol.28 (2), p.504-509
Notes: http://dx.doi.org/10.1111/jvim.12269
istex:A121EDF51D560ED6F691A79A08FB2B2D639EAEA1
ark:/67375/WNG-XZKQ6SK9-Q
ArticleID:JVIM12269
This study was supported by the University of Florida, College of Veterinary Medicine Resident Intramural Competitive Grants Program
Description: BACKGROUND: Levetiracetam is used to manage status epilepticus (SE) and cluster seizures (CS) in humans. The drug might be absorbed after rectal administration and could offer a practical adjunct to rectal administration of diazepam in managing SE and CS. HYPOTHESIS: Levetiracetam is rapidly absorbed after rectal administration in dogs and maintains target serum concentrations for at least 9 hours. ANIMALS: Six healthy privately owned dogs between 2 and 6 years of age and weighing 10–20 kg. METHODS: Levetiracetam (40 mg/kg) was administered rectally and blood samples were obtained immediately before (time zero) and at 10, 20, 40, 60, 90, 180, 360, and 540 minutes after drug administration. Dogs were observed for signs of adverse effects over a 24‐hour period after drug administration. RESULTS: CLEVat 10 minutes was 15.3 ± 5.5 μg/mL (mean, SD) with concentrations in the target range (5–40 μg/mL) for all dogs throughout the sampling period. Cₘₐₓ(36.0 ± 10.7 μg/mL) and Tₘₐₓ(103 ± 31 minutes) values were calculated and 2 disparate groups were appreciated. Dogs with feces in the rectum at the time of drug administration had lower mean Cₘₐₓvalues (26.7 ± 3.4 μg/mL) compared with those without (45.2 ± 4.4 μg/mL). Mild sedation was observed between 60 and 90 minutes without other adverse effects noted. CONCLUSIONS AND CLINICAL IMPORTANCE: This study supports the use of rectally administered levetiracetam in future studies of clinical effectiveness in the management of epileptic dogs.
Publisher: United States: J.B. Lippincott
Language: English

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Levetiracetam Rectal Administration in Healthy Dogs

Peters, R.K ; Schubert, T ; Clemmons, R ; Vickroy, T

United States: J.B. Lippincott

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