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Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

Andersen, Anne Poder ; Moreira, José M. A. ; Pedersen, Stine Falsig

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2014-03, Vol.369 (1638), p.20130098-20130098 [Periódico revisado por pares]

England: The Royal Society

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  • Título:
    Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment
  • Autor: Andersen, Anne Poder ; Moreira, José M. A. ; Pedersen, Stine Falsig
  • Assuntos: Glycolysis ; Homeostasis - physiology ; Humans ; Hydrogen-Ion Concentration ; Hypoxia ; Ion Channels - metabolism ; Ion Channels - physiology ; Ion Transport - physiology ; Metabolism ; Neoplasms - metabolism ; Neoplasms - physiopathology ; Ph-Regulation ; Review ; Signal Transduction - physiology ; Tumor Microenvironment - physiology ; Tumour Stroma
  • É parte de: Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2014-03, Vol.369 (1638), p.20130098-20130098
  • Notas: ark:/67375/V84-7CQ826HW-G
    ArticleID:rstb20130098
    istex:D2B44E8CE8E9704BEF66CDCE605CB44552EB9C53
    href:rstb20130098.pdf
    One contribution of 17 to a Theme Issue ‘Ion channels, transporters and cancer’.
    Theme Issue 'Ion channels, transporters and cancer' compiled and edited by Mustafa B. A. Djamgoz, R. Charles Coombes and Albrecht Schwab
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Major changes in intra- and extracellular pH homoeostasis are shared features of most solid tumours. These changes stem in large part from the metabolic shift of most cancer cells towards glycolytic metabolism and other processes associated with net acid production. In combination with oncogenic signalling and impact from factors in the tumour microenvironment, this upregulates acid-extruding plasma membrane transport proteins which maintain intracellular pH normal or even more alkaline compared with that of normal cells, while in turn acidifying the external microenvironment. Mounting evidence strongly indicates that this contributes significantly to cancer development by favouring e.g. cancer cell migration, invasion and chemotherapy resistance. Finally, while still under-explored, it seems likely that non-cancer cells in the tumour microenvironment also exhibit altered pH regulation and that this may contribute to their malignant properties. Thus, the physical tumour microenvironment and the cancer and stromal cells within it undergo important reciprocal interactions which modulate the tumour pH profile, in turn severely impacting on the course of cancer progression. Here, we summarize recent knowledge of tumour metabolism and the tumour microenvironment, placing it in the context of tumour pH regulation, and discuss how interfering with these properties may be exploited clinically.
  • Editor: England: The Royal Society
  • Idioma: Inglês
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