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Western diet consumption by host vertebrate promotes altered gene expression on Aedes aegypti reducing its lifespan and increasing fertility following blood feeding

Menezes, Alexandre ; Peixoto, Marilia ; Silva, Melissa ; Costa-Bartuli, Emylle ; Oliveira, Cinara Lima ; Walter-Nuno, Ana Beatriz ; Kistenmacker, Nathan da Cruz ; Pereira, Jessica ; Ramos, Isabela ; Paiva-Silva, Gabriela O ; Atella, Geórgia C ; Zancan, Patricia ; Sola-Penna, Mauro ; Gomes, Fabio M

Parasites & vectors, 2024-01, Vol.17 (1), p.12-12, Article 12 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Western diet consumption by host vertebrate promotes altered gene expression on Aedes aegypti reducing its lifespan and increasing fertility following blood feeding
Autor: Menezes, Alexandre ; Peixoto, Marilia ; Silva, Melissa ; Costa-Bartuli, Emylle ; Oliveira, Cinara Lima ; Walter-Nuno, Ana Beatriz ; Kistenmacker, Nathan da Cruz ; Pereira, Jessica ; Ramos, Isabela ; Paiva-Silva, Gabriela O ; Atella, Geórgia C ; Zancan, Patricia ; Sola-Penna, Mauro ; Gomes, Fabio M
Assuntos: Aedes - genetics ; Aedes aegypti ; Animals ; Aquatic insects ; Biology ; Blood ; Blood levels ; Blood plasma ; Complications and side effects ; Components ; Composition ; Diet ; Diet, Western ; Disease transmission ; Enzymes ; Fecundity ; Feeds ; Fertility ; Food intake ; Food processing ; Gene Expression ; Glucose ; Health aspects ; High fat diet ; Hormones ; Humidity ; Immunometabolism ; Infectious diseases ; Ingestion ; Insects ; Insulin ; Insulin resistance ; Insulins ; Life span ; Life spans (Biology) ; Lipids ; Longevity ; Malnutrition ; Meals ; Medical research ; Medicine, Experimental ; Metabolic disorders ; Metabolic Syndrome ; Metabolic syndrome X ; Mice ; Mosquito Vectors - genetics ; Mosquitoes ; Ovaries ; Parameter identification ; Parameters ; Pathogens ; Physiology ; Processed foods ; Risk factors ; Rodent Diseases ; Saccharides ; Sucrose ; Symptoms ; Triglycerides ; Vector capacity ; Vector-borne diseases ; Vectors ; Vertebrates ; Western diet ; Yellow fever
É parte de: Parasites & vectors, 2024-01, Vol.17 (1), p.12-12, Article 12
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The high prevalence of metabolic syndrome in low- and middle-income countries is linked to an increase in Western diet consumption, characterized by a high intake of processed foods, which impacts the levels of blood sugar and lipids, hormones, and cytokines. Hematophagous insect vectors, such as the yellow fever mosquito Aedes aegypti, rely on blood meals for reproduction and development and are therefore exposed to the components of blood plasma. However, the impact of the alteration of blood composition due to malnutrition and metabolic conditions on mosquito biology remains understudied. In this study, we investigated the impact of whole-blood alterations resulting from a Western-type diet on the biology of Ae. aegypti. We kept C57Bl6/J mice on a high-fat, high-sucrose (HFHS) diet for 20 weeks and followed biological parameters, including plasma insulin and lipid levels, insulin tolerance, and weight gain, to validate the development of metabolic syndrome. We further allowed Ae. aegypti mosquitoes to feed on mice and tracked how altered host blood composition modulated parameters of vector capacity. Our findings identified that HFHS-fed mice resulted in reduced mosquito longevity and increased fecundity upon mosquito feeding, which correlated with alteration in the gene expression profile of nutrient sensing and physiological and metabolic markers as studied up to several days after blood ingestion. Our study provides new insights into the overall effect of alterations of blood components on mosquito biology and its implications for the transmission of infectious diseases in conditions where the frequency of Western diet-induced metabolic syndromes is becoming more frequent. These findings highlight the importance of addressing metabolic health to further understand the spread of mosquito-borne illnesses in endemic areas.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Western diet consumption by host vertebrate promotes altered gene expression on Aedes aegypti reducing its lifespan and increasing fertility following blood feeding

Menezes, Alexandre ; Peixoto, Marilia ; Silva, Melissa ; Costa-Bartuli, Emylle ; Oliveira, Cinara Lima ; Walter-Nuno, Ana Beatriz ; Kistenmacker, Nathan da Cruz ; Pereira, Jessica ; Ramos, Isabela ; Paiva-Silva, Gabriela O ; Atella, Geórgia C ; Zancan, Patricia ; Sola-Penna, Mauro ; Gomes, Fabio M

England: BioMed Central Ltd

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