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Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models

Min Ji Jeon ; Bryan R. Haugen

Endocrinology and metabolism (Seoul), 2022-12, Vol.37 (6), p.830-838 [Periódico revisado por pares]

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Título:
Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models
Autor: Min Ji Jeon ; Bryan R. Haugen
Assuntos: animal ; Animals ; Cell line ; genetically modified ; Thyroid neoplasm
É parte de: Endocrinology and metabolism (Seoul), 2022-12, Vol.37 (6), p.830-838
Notas: The Korean Society of Endocrinology
Descrição: The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies. Thus, relevant preclinical models are needed to investigate thyroid cancer biology and novel treatments. Different preclinical models have recently emerged with advances in thyroid cancer genetics, mouse modeling and new cell lines. Choosing the appropriate model according to the research question is crucial to studying thyroid cancer. This review will discuss the current preclinical models frequently used in thyroid cancer research, from cell lines to mouse models, and future perspectives on patient-derived and humanized preclinical models in this field.
Editor: 대한내분비학회
Idioma: Coreano

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