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Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults

Salaverria, Itziar ; Philipp, Claudia ; Oschlies, Ilske ; Kohler, Christian W. ; Kreuz, Markus ; Szczepanowski, Monika ; Burkhardt, Birgit ; Trautmann, Heiko ; Gesk, Stefan ; Andrusiewicz, Miroslaw ; Berger, Hilmar ; Fey, Miriam ; Harder, Lana ; Hasenclever, Dirk ; Hummel, Michael ; Loeffler, Markus ; Mahn, Friederike ; Martin-Guerrero, Idoia ; Pellissery, Shoji ; Pott, Christiane ; Pfreundschuh, Michael ; Reiter, Alfred ; Richter, Julia ; Rosolowski, Maciej ; Schwaenen, Carsten ; Stein, Harald ; Trümper, Lorenz ; Wessendorf, Swen ; Spang, Rainer ; Küppers, Ralf ; Klapper, Wolfram ; Siebert, Reiner

Blood, 2011-07, Vol.118 (1), p.139-147 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults
Autor: Salaverria, Itziar ; Philipp, Claudia ; Oschlies, Ilske ; Kohler, Christian W. ; Kreuz, Markus ; Szczepanowski, Monika ; Burkhardt, Birgit ; Trautmann, Heiko ; Gesk, Stefan ; Andrusiewicz, Miroslaw ; Berger, Hilmar ; Fey, Miriam ; Harder, Lana ; Hasenclever, Dirk ; Hummel, Michael ; Loeffler, Markus ; Mahn, Friederike ; Martin-Guerrero, Idoia ; Pellissery, Shoji ; Pott, Christiane ; Pfreundschuh, Michael ; Reiter, Alfred ; Richter, Julia ; Rosolowski, Maciej ; Schwaenen, Carsten ; Stein, Harald ; Trümper, Lorenz ; Wessendorf, Swen ; Spang, Rainer ; Küppers, Ralf ; Klapper, Wolfram ; Siebert, Reiner
Assuntos: Adolescent ; Adult ; Age of Onset ; Aged ; Base Sequence ; Biological and medical sciences ; Child ; Child, Preschool ; Chromosome aberrations ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 6 ; Female ; Genes, Immunoglobulin Heavy Chain - genetics ; Genes, Immunoglobulin Heavy Chain - immunology ; Germinal Center - pathology ; Hematologic and hematopoietic diseases ; Humans ; Interferon Regulatory Factors - genetics ; Interferon Regulatory Factors - immunology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - immunology ; Lymphoma, B-Cell - pathology ; Male ; Medical genetics ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Oncogene Proteins, Fusion - genetics ; Prognosis ; Translocation, Genetic ; Young Adult
É parte de: Blood, 2011-07, Vol.118 (1), p.139-147
Descrição: The prognosis of germinal center–derived B-cell (GCB) lymphomas, including follicular lymphoma and diffuse large-B-cell lymphoma (DLBCL), strongly depends on age. Children have a more favorable outcome than adults. It is not known whether this is because of differences in host characteristics, treatment protocols, or tumor biology, including the presence of chromosomal alterations. By screening for novel IGH translocation partners in pediatric and adult lymphomas, we identified chromosomal translocations juxtaposing the IRF4 oncogene next to one of the immunoglobulin (IG) loci as a novel recurrent aberration in mature B-cell lymphoma. FISH revealed 20 of 427 lymphomas to carry an IG/IRF4-fusion. Those were predominantly GCB-type DLBCL or follicular lymphoma grade 3, shared strong expression of IRF4/MUM1 and BCL6, and lacked PRDM1/BLIMP1 expression and t(14;18)/BCL2 breaks. BCL6 aberrations were common. The gene expression profile of IG/IRF4-positive lymphomas differed from other subtypes of DLBCL. A classifier for IG/IRF4 positivity containing 27 genes allowed accurate prediction. IG/IRF4 positivity was associated with young age and a favorable outcome. Our results suggest IRF4 translocations to be primary alterations in a molecularly defined subset of GCB-derived lymphomas. The probability for this subtype of lymphoma significantly decreases with age, suggesting that diversity in tumor biology might contribute to the age-dependent differences in prognosis of lymphoma.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults

Washington, DC: Elsevier Inc

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