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Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Postema, Merel C ; Hoogman, Martine ; Ambrosino, Sara ; Asherson, Philip ; Banaschewski, Tobias ; Bandeira, Cibele E ; Baranov, Alexandr ; Bau, Claiton HD ; Baumeister, Sarah ; Baur‐Streubel, Ramona ; Bellgrove, Mark A ; Biederman, Joseph ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Buitelaar, Jan K ; Busatto, Geraldo F ; Castellanos, Francisco X ; Cercignani, Mara ; Chaim‐Avancini, Tiffany M ; Chantiluke, Kaylita C ; Christakou, Anastasia ; Coghill, David ; Conzelmann, Annette ; Cubillo, Ana I ; Cupertino, Renata B ; de Zeeuw, Patrick ; Doyle, Alysa E ; Durston, Sarah ; Earl, Eric A ; Epstein, Jeffery N ; Ethofer, Thomas ; Fair, Damien A ; Fallgatter, Andreas J ; Faraone, Stephen V ; Frodl, Thomas ; Gabel, Matt C ; Gogberashvili, Tinatin ; Grevet, Eugenio H ; Haavik, Jan ; Harrison, Neil A ; Hartman, Catharina A ; Heslenfeld, Dirk J ; Hoekstra, Pieter J ; Hohmann, Sarah ; Høvik, Marie F ; Jernigan, Terry L ; Kardatzki, Bernd ; Karkashadze, Georgii ; Kelly, Clare ; Kohls, Gregor ; Konrad, Kerstin ; Kuntsi, Jonna ; Lazaro, Luisa ; Lera‐Miguel, Sara ; Lesch, Klaus‐Peter ; Louza, Mario R ; Lundervold, Astri J ; Malpas, Charles B ; Mattos, Paulo ; McCarthy, Hazel ; Namazova‐Baranova, Leyla ; Nicolau, Rosa ; Nigg, Joel T ; Novotny, Stephanie E ; Weiss, Eileen Oberwelland ; Tuura, Ruth L O'Gorman ; Oosterlaan, Jaap ; Oranje, Bob ; Paloyelis, Yannis ; Pauli, Paul ; Picon, Felipe A ; Plessen, Kerstin J ; Ramos‐Quiroga, J Antoni ; Reif, Andreas ; Reneman, Liesbeth ; Rosa, Pedro GP ; Rubia, Katya ; Schrantee, Anouk ; Schweren, Lizanne JS ; Seitz, Jochen ; Shaw, Philip ; Silk, Tim J ; Skokauskas, Norbert ; Vila, Juan C Soliva ; Stevens, Michael C ; Sudre, Gustavo ; Tamm, Leanne ; Tovar‐Moll, Fernanda ; van Erp, Theo GM ; Vance, Alasdair ; Vilarroya, Oscar ; Vives‐Gilabert, Yolanda ; von Polier, Georg G ; Walitza, Susanne ; Yoncheva, Yuliya N ; Zanetti, Marcus V ; Ziegler, Georg C ; Glahn, David C ; Jahanshad, Neda

Journal of Child Psychology and Psychiatry, 2021-10, Vol.62 (10), p.1202-1219

eScholarship, University of California

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Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets
Autor: Postema, Merel C ; Hoogman, Martine ; Ambrosino, Sara ; Asherson, Philip ; Banaschewski, Tobias ; Bandeira, Cibele E ; Baranov, Alexandr ; Bau, Claiton HD ; Baumeister, Sarah ; Baur‐Streubel, Ramona ; Bellgrove, Mark A ; Biederman, Joseph ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Buitelaar, Jan K ; Busatto, Geraldo F ; Castellanos, Francisco X ; Cercignani, Mara ; Chaim‐Avancini, Tiffany M ; Chantiluke, Kaylita C ; Christakou, Anastasia ; Coghill, David ; Conzelmann, Annette ; Cubillo, Ana I ; Cupertino, Renata B ; de Zeeuw, Patrick ; Doyle, Alysa E ; Durston, Sarah ; Earl, Eric A ; Epstein, Jeffery N ; Ethofer, Thomas ; Fair, Damien A ; Fallgatter, Andreas J ; Faraone, Stephen V ; Frodl, Thomas ; Gabel, Matt C ; Gogberashvili, Tinatin ; Grevet, Eugenio H ; Haavik, Jan ; Harrison, Neil A ; Hartman, Catharina A ; Heslenfeld, Dirk J ; Hoekstra, Pieter J ; Hohmann, Sarah ; Høvik, Marie F ; Jernigan, Terry L ; Kardatzki, Bernd ; Karkashadze, Georgii ; Kelly, Clare ; Kohls, Gregor ; Konrad, Kerstin ; Kuntsi, Jonna ; Lazaro, Luisa ; Lera‐Miguel, Sara ; Lesch, Klaus‐Peter ; Louza, Mario R ; Lundervold, Astri J ; Malpas, Charles B ; Mattos, Paulo ; McCarthy, Hazel ; Namazova‐Baranova, Leyla ; Nicolau, Rosa ; Nigg, Joel T ; Novotny, Stephanie E ; Weiss, Eileen Oberwelland ; Tuura, Ruth L O'Gorman ; Oosterlaan, Jaap ; Oranje, Bob ; Paloyelis, Yannis ; Pauli, Paul ; Picon, Felipe A ; Plessen, Kerstin J ; Ramos‐Quiroga, J Antoni ; Reif, Andreas ; Reneman, Liesbeth ; Rosa, Pedro GP ; Rubia, Katya ; Schrantee, Anouk ; Schweren, Lizanne JS ; Seitz, Jochen ; Shaw, Philip ; Silk, Tim J ; Skokauskas, Norbert ; Vila, Juan C Soliva ; Stevens, Michael C ; Sudre, Gustavo ; Tamm, Leanne ; Tovar‐Moll, Fernanda ; van Erp, Theo GM ; Vance, Alasdair ; Vilarroya, Oscar ; Vives‐Gilabert, Yolanda ; von Polier, Georg G ; Walitza, Susanne ; Yoncheva, Yuliya N ; Zanetti, Marcus V ; Ziegler, Georg C ; Glahn, David C ; Jahanshad, Neda
Assuntos: 2.1 Biological and endogenous factors ; Adolescent ; Adult ; Aetiology ; Applied and developmental psychology ; Attention Deficit Disorder with Hyperactivity ; Attention Deficit Hyperactivity Disorder (ADHD) ; Attention‐ ; Attention-deficit ; Autism Spectrum Disorder ; Biological Psychology ; Brain ; brain asymmetry ; Brain Disorders ; brain laterality ; Caudate Nucleus ; Child ; Clinical and health psychology ; Clinical Sciences ; Cognitive Sciences ; deficit ; Developmental & Child Psychology ; ENIGMA ADHD Working Group ; Humans ; hyperactivity disorder ; large‐ ; large-scale data ; Magnetic Resonance Imaging ; Mental Health ; Neurosciences ; Pediatric ; Pediatric Research Initiative ; Psychology ; scale data ; structural MRI
É parte de: Journal of Child Psychology and Psychiatry, 2021-10, Vol.62 (10), p.1202-1219
Notas: 1202 - 1219
Journal of Child Psychology and Psychiatry, vol 62, iss 10
Descrição: ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.
Editor: eScholarship, University of California
Idioma: Inglês

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Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

eScholarship, University of California

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