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AMPA receptors mediate passive avoidance deficits induced by sleep deprivation

Dubiela, Francisco Paulino ; Queiroz, Claudio Marcos ; Moreira, Karin Di Monteiro ; Nobrega, Jose N. ; Sita, Luciane Valéria ; Tufik, Sergio ; Hipolide, Debora Cristina

Behavioural brain research, 2013-11, Vol.257, p.189-196 [Periódico revisado por pares]

Shannon: Elsevier B.V

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Título:
AMPA receptors mediate passive avoidance deficits induced by sleep deprivation
Autor: Dubiela, Francisco Paulino ; Queiroz, Claudio Marcos ; Moreira, Karin Di Monteiro ; Nobrega, Jose N. ; Sita, Luciane Valéria ; Tufik, Sergio ; Hipolide, Debora Cristina
Assuntos: AMPA receptor ; Analysis of Variance ; Animals ; Aniracetam ; Avoidance Learning - physiology ; Benzodiazepines - pharmacology ; Biological and medical sciences ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Excitatory Amino Acid Antagonists - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - physiology ; GYKI-52466 ; Learning Disorders - complications ; Learning Disorders - metabolism ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Nootropic Agents - pharmacology ; Passive avoidance task ; Protein Binding - drug effects ; Pyrrolidinones - pharmacology ; Rats ; Rats, Wistar ; Receptors, AMPA - genetics ; Receptors, AMPA - metabolism ; Sleep deprivation ; Sleep Deprivation - complications ; Sleep. Vigilance ; Time Factors ; Tritium - metabolism ; Vertebrates: nervous system and sense organs
É parte de: Behavioural brain research, 2013-11, Vol.257, p.189-196
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Descrição: •[3H]AMPA binding is reduced in the hippocampal formation by sleep deprivation.•Sleep recovery restored [3H]AMPA binding reduction induced by sleep deprivation.•GluR1 mRNA levels are unaffected by sleep deprivation.•AMPAR potentiator reverted sleep deprivation-induced impairment of memory retention.•AMPAR antagonist had no effect on sleep deprivation-induced impairment of memory retention. The present study addressed the effects of sleep deprivation (SD) on AMPA receptor (AMPAR) binding in brain regions associated with learning and memory, and investigated whether treatment with drugs acting on AMPAR could prevent passive avoidance deficits in sleep deprived animals. [3H]AMPA binding and GluR1 in situ hybridization signals were quantified in different brain regions of male Wistar rats either immediately after 96h of sleep deprivation or after 24h of sleep recovery following 96h of sleep deprivation. Another group of animals were sleep deprived and then treated with either the AMPAR potentiator, aniracetam (25, 50 and 100mg/kg, acute administration) or the AMPAR antagonist GYKI-52466 (5 and 10mg/kg, acute and chronic administration) before passive avoidance training. Task performance was evaluated 2h and 24h after training. A significant reduction in [3H]AMPA binding was found in the hippocampal formation of SD animals, while no alterations were observed in GluR1 mRNA levels. The highest dose of aniracetam (100mg/kg) reverted SD-induced impairment of passive avoidance performance in both retention tests, whereas GYKI-52466 treatment had no effect. Pharmacological enhancement of AMPAR function may revert hippocampal-dependent learning impairments produced after SD. We argue that such effects might be associated with reduced AMPAR binding in the hippocampus of sleep deprived animals.
Editor: Shannon: Elsevier B.V
Idioma: Inglês

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AMPA receptors mediate passive avoidance deficits induced by sleep deprivation

Dubiela, Francisco Paulino ; Queiroz, Claudio Marcos ; Moreira, Karin Di Monteiro ; Nobrega, Jose N. ; Sita, Luciane Valéria ; Tufik, Sergio ; Hipolide, Debora Cristina

Shannon: Elsevier B.V

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