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The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

WARNE, Tony ; MOUKHAMETZIANOV, Rouslan ; BAKER, Jillian G ; NEHME, Rony ; EDWARDS, Patricia C ; LESLIE, Andrew G. W ; SCHERTLER, Gebhard F. X ; TATE, Christopher G

Nature (London), 2011-01, Vol.469 (7329), p.241-244 [Periódico revisado por pares]

London: Nature Publishing Group

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  • Título:
    The structural basis for agonist and partial agonist action on a β1-adrenergic receptor
  • Autor: WARNE, Tony ; MOUKHAMETZIANOV, Rouslan ; BAKER, Jillian G ; NEHME, Rony ; EDWARDS, Patricia C ; LESLIE, Andrew G. W ; SCHERTLER, Gebhard F. X ; TATE, Christopher G
  • Assuntos: Biological and medical sciences ; Crystalline structure ; Fundamental and applied biological sciences. Psychology ; Molecular biophysics ; Structure in molecular biology
  • É parte de: Nature (London), 2011-01, Vol.469 (7329), p.241-244
  • Notas: Author Information: Co-ordinates and structure factors have been submitted to the PDB database under accession codes 2y00, 2y01, 2y02, 2y03 and 2y04 for β44-m23 bound either to dobutamine (dob92 and dob102), carmoterol, isoprenaline or salbutamol, respectively.
    Author contributions: T.W. devised and performed receptor expression, purification, crystallization, cryo-cooling of the crystals, data collection and initial data processing. P.C.E. helped with crystal cryo-cooling and data collection. J.G.B. performed the pharmacological analyses on receptor mutants in whole cells and R.N. performed the ligand binding studies on baculovirus-expressed receptors. R.M. and A.G.W.L. were involved in data processing and structure refinement. Manuscript preparation was performed by T.W., C.G.T., A.G.W.L. and G.F.X.S. The overall project management was by G.F.X.S. and C.G.T.
    Current Address: Paul Scherrer Institut, Laboratory of Biomolecular Research, BMR, OFLC 109, CH-5232 Villigen PSI, Switzerland, Telephone +41 (0)56 310 4265
  • Editor: London: Nature Publishing Group
  • Idioma: Inglês
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