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Proteins Potentially Involved in Immune Evasion Strategies in Sporothrix brasiliensis Elucidated by Ultra-High-Resolution Mass Spectrometry

Rossato, Luana ; Moreno, Leandro Ferreira ; Jamalian, Azadeh ; Stielow, Benjamin ; de Almeida, Sandro Rogério ; de Hoog, Sybren ; Freeke, Joanna Bahn, Yong-Sun

mSphere, 2018-06, Vol.3 (3) [Periódico revisado por pares]

United States: American Society for Microbiology

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  • Título:
    Proteins Potentially Involved in Immune Evasion Strategies in Sporothrix brasiliensis Elucidated by Ultra-High-Resolution Mass Spectrometry
  • Autor: Rossato, Luana ; Moreno, Leandro Ferreira ; Jamalian, Azadeh ; Stielow, Benjamin ; de Almeida, Sandro Rogério ; de Hoog, Sybren ; Freeke, Joanna
  • Bahn, Yong-Sun
  • Assuntos: Cats ; Coccidioides ; Epidemics ; Fungi ; Genes ; Genomics ; Immune evasion ; Immune system ; Mammals ; Mass spectrometry ; Mass spectroscopy ; Outbreaks ; Peptides ; Proteins ; Proteomics ; Scientific imaging ; Sporothrix ; Sporothrix brasiliensis ; Sporothrix globosa ; Sporothrix schenckii ; Sporotrichosis ; Virulence ; Yeast ; Zoonoses
  • É parte de: mSphere, 2018-06, Vol.3 (3)
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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    Citation Rossato L, Moreno LF, Jamalian A, Stielow B, de Almeida SR, de Hoog S, Freeke J. 2018. Proteins potentially involved in immune evasion strategies in Sporothrix brasiliensis elucidated by ultra-high-resolution mass spectrometry. mSphere 3:e00514-17. https://doi.org/10.1128/mSphere.00514-17.
  • Descrição: is the prevalent agent of a large zoonotic outbreak in Brazil. With the involvement of several thousands of cases, this is the largest cohort of human and animal sporotrichosis on record in the world. Infections are characterized by local cutaneous dissemination in humans without underlying disease. has shown a high degree of virulence in a mouse model compared to the remaining species, including the ancestral species, The present paper investigates a genomic and expressed-proteome comparison of to Using bottom-up proteomics, we found 60 proteins exclusively expressed in No significant genomic differences were found among the genes coding for this protein set. A comparison with literature data identified nine proteins that are known to be involved in virulence and immune evasion in other species, several of which had not yet been reported for the species analyzed. Sporotrichosis is an important disease in Brazil that is caused by fungi of the genus and affects cats and humans. Our work investigated the proteins differentially expressed by in order to find out why this species is more virulent and pathogenic than We verified a set of proteins that may be related to immune escape and that can explain the high virulence.
  • Editor: United States: American Society for Microbiology
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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