skip to main content
Idioma:

Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma

Gadbail, Amol Ramchandra; Sarode, Sachin C; Chaudhary, Minal S; Gondivkar, Shailesh M; Tekade, Satyajit Ashok; Yuwanati, Monal; Patil, Shankargouda

Journal of Applied Oral Science; v. 29 (2021); e20200751

Universidade de São Paulo. Faculdade de Odontologia de Bauru 2021-06-14

Acesso online

  • Título:
    Ki67 Labelling Index predicts clinical outcome and survival in oral squamous cell carcinoma
  • Autor: Gadbail, Amol Ramchandra; Sarode, Sachin C; Chaudhary, Minal S; Gondivkar, Shailesh M; Tekade, Satyajit Ashok; Yuwanati, Monal; Patil, Shankargouda
  • Assuntos: Oral Squamous Cell Carcinoma; Ki67 Labelling Index; Proliferation; Prognosis; Survival
  • É parte de: Journal of Applied Oral Science; v. 29 (2021); e20200751
  • Descrição: Objective: To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). Methodology: Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. Results: The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p<0.001), clinical TNM staging (p<0.001) and nodal metastasis (p<0.001). The OSCC patients survived for less than 3 and 5 years were showed significantly higher Ki67 LI as compared to diseases free survived more than 3 and 5 years(p<0.001). The three years survival rate of OSCC patient significantly higher with low Ki67 LI (≤45) 96.2%, followed by moderate Ki67 LI (46 to 60) 60.7% and high Ki67 LI (≥61) 37.7% (p<0.001). The five years survival rate of OSCC patient statistically significantly higher with low Ki67 LI (≤45)93.3%, followed by moderate Ki67 LI (46 to 60) 46.8% and Ki67 LI (≥61) 23.3% (p<0.001). Conclusion: The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC.
  • Títulos relacionados: https://www.revistas.usp.br/jaos/article/view/187143/172912
  • Editor: Universidade de São Paulo. Faculdade de Odontologia de Bauru
  • Data de criação/publicação: 2021-06-14
  • Formato: Adobe PDF
  • Idioma: Inglês
Links
Voltar para lista de resultados
Resultado  1 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.