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Alternative Synthesis of Substance P

KITAGAWA, KOUKI ; BAN, YUKO ; AKITA, TADASHI ; SEGAWA, TOMIO ; NAKATA, YOSHIHIRO ; YAJIMA, HARUAKI

Chemical and Pharmaceutical Bulletin, 1978/05/25, Vol.26(5), pp.1604-1607 [Periódico revisado por pares]

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Título:
Alternative Synthesis of Substance P
Autor: KITAGAWA, KOUKI ; BAN, YUKO ; AKITA, TADASHI ; SEGAWA, TOMIO ; NAKATA, YOSHIHIRO ; YAJIMA, HARUAKI
Assuntos: smooth muscle contractile activity
É parte de: Chemical and Pharmaceutical Bulletin, 1978/05/25, Vol.26(5), pp.1604-1607
Descrição: A bovine hypothalamic peptide, substance P was synthesized alternatively by successive condensation of three subunits, N-terminal di-, middle hepta- and C-terminal dipeptides. Two newly synthesized peptides, PCA-Phe-Phe-Gly-Leu-Met-NH2 and PCA-Gln-Phe-Phe-Gly-Leu-Met-NH2 were both found to be approximately two times active than synthetic substance P, when the contractile activity was determined in isolated guinea-pig ileum.
Editor: Tokyo: The Pharmaceutical Society of Japan
Idioma: Inglês

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