Idioma:

10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity

JOO, JI-HYE ; HONG, SEONG-SU ; CHO, YOUNG-RAK ; SEO, DONG-WAN

Oncology reports, 2016-02, Vol.35 (2), p.779-784 [Periódico revisado por pares]

Greece: D.A. Spandidos

Texto completo disponível

Citações Citado por

Enviar para

Título:
10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity
Autor: JOO, JI-HYE ; HONG, SEONG-SU ; CHO, YOUNG-RAK ; SEO, DONG-WAN
Assuntos: 10-gingerol ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis ; Blotting, Western ; Breast cancer ; Breast Neoplasms - pathology ; Cancer therapies ; Catechols - pharmacology ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chromatography ; epidermal growth factor receptor ; Fatty Alcohols - pharmacology ; Female ; Humans ; Kinases ; Magnetic Resonance Spectroscopy ; Neoplasm Invasiveness - pathology ; p38 Mitogen-Activated Protein Kinases - drug effects ; p38 Mitogen-Activated Protein Kinases - metabolism ; Proto-Oncogene Proteins c-akt - drug effects ; Proto-Oncogene Proteins c-akt - metabolism
É parte de: Oncology reports, 2016-02, Vol.35 (2), p.779-784
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In the present study, we investigated the roles and molecular mechanism of 10-gingerol, a phenolic compound isolated from Zingiber officinale, in regulating cell proliferation and invasion of MDA-MB-231 breast cancer cells. 10-gingerol treatment inhibited cell proliferation through downregulation of cell cycle regulatory proteins such as cyclin-dependent kinases and cyclins, and subsequent induction of G1 phase arrest. In addition, 10-gingerol treatment blocked cell invasion in response to mitogenic stimulation. These antitumor activities of 10-gingerol were mediated through inactivation of Akt and p38MAPK activity, and suppression of epidermal growth factor receptor expression. Collectively, these findings demonstrate the pharmacological roles of 10-gingerol in regulating breast cancer cell growth and progression, and suggest further evaluation and development as a potential therapeutic agent for the prevention and treatment of breast cancer.
Editor: Greece: D.A. Spandidos
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity

JOO, JI-HYE ; HONG, SEONG-SU ; CHO, YOUNG-RAK ; SEO, DONG-WAN

Greece: D.A. Spandidos

Buscando em bases de dados remotas. Favor aguardar.