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[ 123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa

Tauscher, Johannes ; Pirker, Walter ; Willeit, Matthäus ; de Zwaan, Martina ; Bailer, Ursula ; Neumeister, Alexander ; Asenbaum, Susanne ; Lennkh, Claudia ; Praschak-Rieder, Nicole ; Brücke, Thomas ; Kasper, Siegfried

Biological psychiatry (1969), 2001-02, Vol.49 (4), p.326-332 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
[ 123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa
Autor: Tauscher, Johannes ; Pirker, Walter ; Willeit, Matthäus ; de Zwaan, Martina ; Bailer, Ursula ; Neumeister, Alexander ; Asenbaum, Susanne ; Lennkh, Claudia ; Praschak-Rieder, Nicole ; Brücke, Thomas ; Kasper, Siegfried
Assuntos: [ 123I] β-CIT ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Binding, Competitive - physiology ; Biological and medical sciences ; Biological Transport, Active - physiology ; Brain - metabolism ; Bulimia ; Bulimia - metabolism ; Bulimia - therapy ; Bulimia nervosa ; Carrier Proteins - metabolism ; Cerebellum - metabolism ; Cognitive Behavioral Therapy ; Depression - diagnosis ; Depression - psychology ; Eating behavior disorders ; eating disorders ; Female ; Humans ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiopharmaceuticals ; Serotonin - metabolism ; serotonin transporter ; SPECT ; Tomography, Emission-Computed, Single-Photon
É parte de: Biological psychiatry (1969), 2001-02, Vol.49 (4), p.326-332
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background: Impaired serotonin transmission has been implicated in the pathophysiology of eating disorders. We investigated the in vivo availability of brain serotonin transporters and dopamine transporters in bulimia nervosa patients. Methods: Approximately 24 hours after injection of [ 123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane ([ 123I] β-CIT), single photon emission computed tomography scans were performed in 10 medication-free, female bulimic patients and 10 age-matched, healthy females. For quantification of brain serotonin transporter and dopamine transporter availability, a ratio of specific to nonspecific [ 123I] β-CIT brain binding was used (V 3″ = target region − cerebellum/cerebellum). Results: Drug-free bulimia nervosa patients showed a 17% reduced brain serotonin transporter availability in the hypothalamus and thalamus, as compared with healthy control subjects (2.4 ± 0.4 vs. 2.9 ± 0.4, p = .026), and a similar reduction in striatal dopamine transporter availability. There was a negative correlation of illness duration and serotonin transporter availability ( r = −.65; p = .042) and a strong positive correlation between hypothalamic/thalamic and striatal V 3″ ( r = .80, p < .001). Conclusions: This first report of reduced [ 123I] β-CIT binding in a relatively small group of patients with bulimia nervosa suggests a reduced hypothalamic and thalamic serotonin transporter availability in bulimia, which is more pronounced with longer duration of illness.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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[ 123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa

Tauscher, Johannes ; Pirker, Walter ; Willeit, Matthäus ; de Zwaan, Martina ; Bailer, Ursula ; Neumeister, Alexander ; Asenbaum, Susanne ; Lennkh, Claudia ; Praschak-Rieder, Nicole ; Brücke, Thomas ; Kasper, Siegfried

New York, NY: Elsevier Inc

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