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Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men

Imoukhuede, E.B. ; Berthoud, T. ; Milligan, P. ; Bojang, K. ; Ismaili, J. ; Keating, S. ; Nwakanma, D. ; Keita, S. ; Njie, F. ; Sowe, M. ; Todryk, S. ; Laidlaw, S.M. ; Skinner, M.A. ; Lang, T. ; Gilbert, S. ; Greenwood, B.M. ; Hill, A.V.S.

Vaccine, 2006-10, Vol.24 (42), p.6526-6533 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men
Autor: Imoukhuede, E.B. ; Berthoud, T. ; Milligan, P. ; Bojang, K. ; Ismaili, J. ; Keating, S. ; Nwakanma, D. ; Keita, S. ; Njie, F. ; Sowe, M. ; Todryk, S. ; Laidlaw, S.M. ; Skinner, M.A. ; Lang, T. ; Gilbert, S. ; Greenwood, B.M. ; Hill, A.V.S.
Assuntos: Adult ; Animals ; Antibodies, Protozoan - biosynthesis ; Antibody Specificity ; Applied microbiology ; Biological and medical sciences ; Cross Reactions ; Dose-Response Relationship, Immunologic ; Enzyme-Linked Immunosorbent Assay ; Fundamental and applied biological sciences. Psychology ; Gambia ; Human protozoal diseases ; Humans ; Immunity, Cellular - immunology ; Immunization ; Immunization, Secondary ; Immunogenicity ; Immunoglobulin G - analysis ; Immunoglobulin G - biosynthesis ; Infectious diseases ; Interferon-gamma ; Malaria ; Malaria vaccines ; Malaria Vaccines - adverse effects ; Malaria Vaccines - immunology ; Malaria, Falciparum - immunology ; Malaria, Falciparum - prevention & control ; Male ; Medical sciences ; Medical tests ; Meetings ; Microbiology ; Parasitic diseases ; Phenotype ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; Prime-boost ; Proteins ; Protozoal diseases ; Studies ; T-Lymphocytes - immunology ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccinia virus ; Volunteers
É parte de: Vaccine, 2006-10, Vol.24 (42), p.6526-6533
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We assessed the safety and immunogenicity of prime-boost vectors encoding the Plasmodium falciparum circumsporozoite (CS) protein expressed either in the attenuated fowl-pox virus (FP9) or modified vaccinia virus Ankara (MVA). Thirty-two adult Gambians in groups of four to eight received one, two or three doses of FP9 CS and/or MVA CS. No serious adverse event was observed following vaccination. The most immunogenic regimen was two doses of FP9 followed by a single dose of MVA 4 weeks later (an average of 1000 IFN-γ spot forming units/million PBMCs). This level of effector T-cell responses appears higher than that seen in previously reported studies of CS-based candidate malaria vaccines.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Safety and immunogenicity of the malaria candidate vaccines FP9 CS and MVA CS in adult Gambian men

Imoukhuede, E.B. ; Berthoud, T. ; Milligan, P. ; Bojang, K. ; Ismaili, J. ; Keating, S. ; Nwakanma, D. ; Keita, S. ; Njie, F. ; Sowe, M. ; Todryk, S. ; Laidlaw, S.M. ; Skinner, M.A. ; Lang, T. ; Gilbert, S. ; Greenwood, B.M. ; Hill, A.V.S.

Oxford: Elsevier Ltd

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