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Leptin and ghrelin prevent hippocampal dysfunction induced by Aβ oligomers

Martins, I ; Gomes, S ; Costa, R.O ; Otvos, L ; Oliveira, C.R ; Resende, R ; Pereira, C.M.F

Neuroscience, 2013-06, Vol.241, p.41-51 [Periódico revisado por pares]

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Título:
Leptin and ghrelin prevent hippocampal dysfunction induced by Aβ oligomers
Autor: Martins, I ; Gomes, S ; Costa, R.O ; Otvos, L ; Oliveira, C.R ; Resende, R ; Pereira, C.M.F
Assuntos: Alzheimer Disease - metabolism ; Alzheimer’s disease ; Amyloid beta-Peptides - toxicity ; amyloid-beta oligomers ; Animals ; Blotting, Western ; Cell Survival - drug effects ; Cells, Cultured ; ghrelin ; Ghrelin - metabolism ; Ghrelin - pharmacology ; hippocampus ; Hippocampus - pathology ; leptin ; Leptin - metabolism ; Leptin - pharmacology ; Neurology ; Neurons - drug effects ; Neurons - metabolism ; Peptide Fragments - toxicity ; Protein Multimerization ; Rats ; Rats, Wistar
É parte de: Neuroscience, 2013-06, Vol.241, p.41-51
Descrição: Highlights • Leptin and ghrelin protect hippocampal neurons from Aβ oligomers-induced toxicity. • Leptin and ghrelin prevent oxidative stress and mitochondrial dysfunction. • Leptin and ghrelin revert GSK3β activation induced by Aβ oligomers. • Neuroprotection by leptin and ghrelin occurs in a receptor-mediated manner.
Editor: United States: Elsevier Ltd
Idioma: Inglês

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