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Preparation of polyaniline submicro/nanostructures using l-glutamic acid: Loading and releasing studies of amoxicillin

Pérez-Martínez, C.J. ; del Castillo-Castro, T. ; Castillo-Ortega, M.M. ; Rodríguez-Félix, D.E. ; Herrera-Franco, P.J. ; Ovando-Medina, V.M.

Synthetic metals, 2013-11, Vol.184, p.41-47 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Preparation of polyaniline submicro/nanostructures using l-glutamic acid: Loading and releasing studies of amoxicillin
Autor: Pérez-Martínez, C.J. ; del Castillo-Castro, T. ; Castillo-Ortega, M.M. ; Rodríguez-Félix, D.E. ; Herrera-Franco, P.J. ; Ovando-Medina, V.M.
Assuntos: Amoxicillin ; Applied sciences ; Biological and medical sciences ; Drug controlled release ; Exact sciences and technology ; General pharmacology ; Medical sciences ; Nanostructures ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polyaniline ; Polymers with particular properties ; Preparation, kinetics, thermodynamics, mechanism and catalysts
É parte de: Synthetic metals, 2013-11, Vol.184, p.41-47
Descrição: •Hybrid submicro/nanostructures of polyaniline and l-glutamic acid were chemically obtained with ammonium persulfate.•The oxidation of aniline in presence of l-glutamic acid produced submicro/nanostructures of cylindrical profile.•The monomer:amino acid:oxidant molar ratio affected the morphological, optical and electrical properties of polyaniline.•The fibrillar structures of glutamic acid coated-polyaniline efficiently adsorbed therapeutic doses of amoxicillin.•Controlled release of the drug can be achieved in function of pH environment. Hybrid submicro/nanostructures of polyaniline (PANI) and l-glutamic acid (GA) were chemically prepared with the addition of ammonium persulfate (APS) as the oxidant. Different GA and APS concentrations were investigated in order to obtain the optimal conditions for the formation of high aspect ratio structures. TEM, electrical and XPS characterizations revealed that at monomer:amino acid:oxidant molar ratio of 1:0.25:1, the PANI presented a fibrillar morphology with diameters in submicro and nanometric scale, the structures were coating with the GA and the GA doped the PANI backbone. The fibrillar structures of GA coated-PANI efficiently adsorbed therapeutic doses of amoxicillin and controlled release of the drug can be achieved in function of pH environment, with a maximum cumulative release of 98% at pH 9 within 48h.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Preparation of polyaniline submicro/nanostructures using l-glutamic acid: Loading and releasing studies of amoxicillin

Pérez-Martínez, C.J. ; del Castillo-Castro, T. ; Castillo-Ortega, M.M. ; Rodríguez-Félix, D.E. ; Herrera-Franco, P.J. ; Ovando-Medina, V.M.

Amsterdam: Elsevier B.V

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