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Evaluation of T‐cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis

BARRAL, ALDINA ; JESUS, AMÉLIA R. ; ALMEIDA, R. P. ; CARVALHO, E. M. ; BARRAL‐NETTO, M. ; COSTA, J. M. L. ; BADARO, R. ; ROCHA, H. ; JOHNSON, W. D.

Parasite immunology, 1987-07, Vol.9 (4), p.487-497 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Evaluation of T‐cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis
Autor: BARRAL, ALDINA ; JESUS, AMÉLIA R. ; ALMEIDA, R. P. ; CARVALHO, E. M. ; BARRAL‐NETTO, M. ; COSTA, J. M. L. ; BADARO, R. ; ROCHA, H. ; JOHNSON, W. D.
Assuntos: Adolescent ; Adult ; Biological and medical sciences ; Biopsy ; Child ; Child, Preschool ; cutaneous leishmaniasis ; Dermatology ; Female ; Human protozoal diseases ; Humans ; Immunoenzyme Techniques ; Infectious diseases ; Leishmania ; Leishmania braziliensis ; Leishmania mexicana ; Leishmaniasis - immunology ; Leishmaniasis - pathology ; Leishmaniasis, Mucocutaneous - immunology ; Leishmaniasis, Mucocutaneous - pathology ; Leshmaniasis ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; mucocutaneous leishmaniasis ; Nasal Mucosa - pathology ; Parasitic diseases ; Phenotype ; Protozoal diseases ; Skin - pathology ; Skin involvement in other diseases. Miscellaneous. General aspects ; T-Lymphocytes - classification ; T-Lymphocytes - immunology ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Regulatory - immunology ; Tropical medicine ; T‐cell subsets
É parte de: Parasite immunology, 1987-07, Vol.9 (4), p.487-497
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Descrição: Summary We have characterized the T‐lymphocytes in the skin lesions of 10 patients with cutaneous leishmaniasis and in the nasal lesions of seven patients with mucosal leishmaniasis. with the immunoperoxidase and monoclonal antibody techniques. There was predominance of cells with helper phenotype (Leu 3A + 3B) over suppressor phenotype (Leu 2a) in the lesions of both groups. The helper/suppressor (H/S) ratio in the skin lesions was 1±6 ± 0±5 and in the nasal lesions of mucosal leishmaniasis was 1±7 ± 0±8. The H/S ratios in the peripheral blood of patients with cutaneous leishmaniasis (2±1 ± 0±8) and in patients with mucosal leishmaniasis (1±6 ± 0±8) were comparable and similar to the ratios in the skin and nasal biopsies. The percentage of T‐cells and macrophages expressing the Dr antigen in the cutaneous group (69±5 ± 13±7) was not significantly different from the mucosal patients (90±3 ± 5±7). We conclude that the immunopathology of the skin lesions in cutaneous leishmaniasis is similar to the nasal lesions of mucosal leishmaniasis.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Evaluation of T‐cell subsets in the lesion infiltrates of human cutaneous and mucocutaneous leishmaniasis

BARRAL, ALDINA ; JESUS, AMÉLIA R. ; ALMEIDA, R. P. ; CARVALHO, E. M. ; BARRAL‐NETTO, M. ; COSTA, J. M. L. ; BADARO, R. ; ROCHA, H. ; JOHNSON, W. D.

Oxford, UK: Blackwell Publishing Ltd

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