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[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum

dos S. Beirigo, Pâmela J ; Torquato, Heron F. V ; dos Santos, Carlos H. C ; Carvalho, Mário G. de ; Castro, Rosane N ; Paredes-Gamero, Edgar J ; de Sousa, Paulo T ; Jacinto, Marcos J ; da Silva, Virgínia C

Journal of natural products (Washington, D.C.), 2016-05, Vol.79 (5), p.1454-1458 [Periódico revisado por pares]

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Título:
[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum
Autor: dos S. Beirigo, Pâmela J ; Torquato, Heron F. V ; dos Santos, Carlos H. C ; Carvalho, Mário G. de ; Castro, Rosane N ; Paredes-Gamero, Edgar J ; de Sousa, Paulo T ; Jacinto, Marcos J ; da Silva, Virgínia C
Assuntos: Apoptosis - drug effects ; Brazil ; DNA - analysis ; Humans ; Jurkat Cells ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - isolation & purification ; Peptides, Cyclic - pharmacology ; Plant Leaves - chemistry ; Zanthoxylum - chemistry
É parte de: Journal of natural products (Washington, D.C.), 2016-05, Vol.79 (5), p.1454-1458
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey’s method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).
Editor: United States: American Chemical Society and American Society of Pharmacognosy
Idioma: Inglês

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