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Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS

Michel, Claire ; Robin, Marie ; Morisset, Stephane ; Blaise, Didier ; Maertens, Johan ; Chevalier, Patrice ; Castilla-Llorente, Cristina ; Forcade, Edouard ; Ceballos, Patrice ; Yakoug-Agha, Ibrahim ; Poire, Xavier ; Carre, Martin ; Bay, Jacques-Olivier ; Beguin, Yves ; Loschi, Michael ; Huynh, Anne ; Guillerm, Gaëlle ; François, Sylvie ; Mear, Jean-Baptiste ; Duléry, Rémy ; Suarez, Felipe ; Bilger, Karin ; Cornillon, Jérôme ; Chalandon, Yves ; Maillard, Natacha ; Labussière-Wallet, Hélène ; Charbonnier, Amandine ; Turlure, Pascal ; Berceanu, Ana ; Chantepie, Sylvain ; Maury, Sébastien ; Bazarbachi, Ali ; Menard, Anne-Lise ; Nguyen-Quoc, Stephanie ; Rubio, Marie-Thérèse ; D'Aveni, Maud

Bone marrow transplantation (Basingstoke), 2023-05, Vol.58 (5), p.534-543 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS
Autor: Michel, Claire ; Robin, Marie ; Morisset, Stephane ; Blaise, Didier ; Maertens, Johan ; Chevalier, Patrice ; Castilla-Llorente, Cristina ; Forcade, Edouard ; Ceballos, Patrice ; Yakoug-Agha, Ibrahim ; Poire, Xavier ; Carre, Martin ; Bay, Jacques-Olivier ; Beguin, Yves ; Loschi, Michael ; Huynh, Anne ; Guillerm, Gaëlle ; François, Sylvie ; Mear, Jean-Baptiste ; Duléry, Rémy ; Suarez, Felipe ; Bilger, Karin ; Cornillon, Jérôme ; Chalandon, Yves ; Maillard, Natacha ; Labussière-Wallet, Hélène ; Charbonnier, Amandine ; Turlure, Pascal ; Berceanu, Ana ; Chantepie, Sylvain ; Maury, Sébastien ; Bazarbachi, Ali ; Menard, Anne-Lise ; Nguyen-Quoc, Stephanie ; Rubio, Marie-Thérèse ; D'Aveni, Maud
Assuntos: Abnormalities ; Acute Disease ; Allografts ; Donors ; Graft vs Host Disease ; Graft vs Host Disease - etiology ; Graft-versus-host reaction ; Hematology ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic stem cells ; Histocompatibility antigen HLA ; Human health sciences ; Humans ; Hématologie ; Karyotypes ; Leukemia ; Leukemia, Myeloid, Acute ; Leukemia, Myeloid, Acute - complications ; Mud ; Myelodysplastic syndrome ; Myelodysplastic syndromes ; Retrospective Studies ; Risk ; Sciences de la santé humaine ; Siblings ; Stem cell transplantation ; Stem cells ; Survival ; Tissue Donors ; Transplantation ; Transplantation Conditioning ; Transplantation Conditioning - methods ; Transplantation, Homologous ; Transplantation, Homologous - methods ; Unrelated Donors
É parte de: Bone marrow transplantation (Basingstoke), 2023-05, Vol.58 (5), p.534-543
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
scopus-id:2-s2.0-85147774939
Descrição: Allogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increasingly used in acute leukemia (AL) and has similar results as using HLA-matched donors, but data on higher-risk MDS is sparse. We compared outcomes in 266 patients with higher-risk MDS after HLA-matched sibling donor (MSD, n = 79), HLA-matched unrelated donor (MUD, n = 139) and HLA haploidentical donor (HID, n = 48) from 2010 to 2019. Median donor age differed between the three groups (p < 0.001). The overall survival was significantly different between the three groups with a better OS observed in the MUD group (p = 0.014). This observation could be explained by a higher progression-free survival with MUD (p = 0.014). The cumulative incidence of grade 2-4 acute GvHD was significantly higher in the HID group (p = 0.051). However, in multivariable analysis, patients transplanted using an HID had comparable mortality to patients transplanted using a MUD (subdistribution hazard ratio [sHR]: 0.58 [0.32-1.07]; p = 0.080) and a MSD ([sHR]: 0.56 [0.28-1.11]; p = 0.094). MUD do not remain a significant positive predictor of survival, suggesting that beyond the donor-recipient HLA matching, the donor age might impact recipient outcome.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS

England: Nature Publishing Group

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