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Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta‐analysis

Ramos‐Garcia, Pablo ; Roca‐Rodriguez, Maria del Mar ; Aguilar‐Diosdado, Manuel ; Gonzalez‐Moles, Miguel Angel

Oral diseases, 2021-04, Vol.27 (3), p.404-421 [Periódico revisado por pares]

Denmark: Wiley Subscription Services, Inc

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  • Título:
    Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta‐analysis
  • Autor: Ramos‐Garcia, Pablo ; Roca‐Rodriguez, Maria del Mar ; Aguilar‐Diosdado, Manuel ; Gonzalez‐Moles, Miguel Angel
  • Assuntos: Dentistry ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Erythroplasia ; Humans ; Leukokeratosis ; leukoplakia ; Lichen planus ; Lichen Planus, Oral ; Meta-analysis ; Mortality ; Mouth Diseases ; mouth neoplasms ; Mouth Neoplasms - complications ; Mouth Neoplasms - epidemiology ; oral ; Oral cancer ; oral submucous fibrosis ; Stents ; systematic review
  • É parte de: Oral diseases, 2021-04, Vol.27 (3), p.404-421
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    ObjectType-Review-4
    content type line 23
    ObjectType-Undefined-3
  • Descrição: The objective was to evaluate current evidence on the prevalence and risk of oral cancer and potentially malignant oral disorders among patients with diabetes mellitus. We searched PubMed, Embase, Web of Science, and Scopus for observational studies published before November 2019. We evaluated the study quality using GRADE, QUIPS, and a specific method for systematic reviews addressing prevalence questions. Meta‐analyses were conducted, and heterogeneity and publication bias were examined. A total of 1,489 studies were found, 116 analyzed in full text, 52 included in qualitative synthesis and 49 meta‐analyzed. Pooled prevalence (PP) of oral cancer in patients with diabetic was 0.25% (95% CI = 0.15–0.39)—250 per 100,000 patients with diabetes mellitus —with a greater chance of oral cancer among patients with diabetes mellitus (OR = 1.41 [95% CI = 1.10–1.81], p = .007). Patients with oral cancer and diabetes mellitus had a higher mortality than controls (HR = 2.09 [95%CI = 1.36–3.22], p = .001). Leukoplakia had a PP = 2.49% (95% CI = 1.14–4.29)—2,490 per 100,000 patients with diabetes mellitus —(OR = 4.34 [95% CI = 1.14–16.55], p = .03). A PP of 2.72 (95% CI = 1.64–4.02) was obtained for oral lichen planus among patients with diabetic —2,720 per 100,000 patients with diabetes mellitus (OR = 1.87 [95% CI = 1.37–2.57], p < .001). A low PP was estimated for erythroplakia (0.02%[95%CI = 0.00–0.12]—20 per 100,000 patients with diabetes mellitus. In conclusion, patients with diabetes mellitus have a higher prevalence and greater chance of oral cancer and OPMD development in comparison with non‐diabetic patients. In addition, patients with oral cancer suffering from diabetes mellitus have a higher mortality compared to non‐diabetic patients with oral cancer.
  • Editor: Denmark: Wiley Subscription Services, Inc
  • Idioma: Inglês
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