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Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats

Yokoe, Jun-ichi ; Sakuragi, Shiho ; Yamamoto, Kayoko ; Teragaki, Takuya ; Ogawara, Ken-ichi ; Higaki, Kazutaka ; Katayama, Naohisa ; Kai, Toshiya ; Sato, Makoto ; Kimura, Toshikiro

International journal of pharmaceutics, 2008-04, Vol.353 (1), p.28-34 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats
Autor: Yokoe, Jun-ichi ; Sakuragi, Shiho ; Yamamoto, Kayoko ; Teragaki, Takuya ; Ogawara, Ken-ichi ; Higaki, Kazutaka ; Katayama, Naohisa ; Kai, Toshiya ; Sato, Makoto ; Kimura, Toshikiro
Assuntos: Animals ; Biological and medical sciences ; Doxorubicin ; Doxorubicin - administration & dosage ; Doxorubicin - analogs & derivatives ; Doxorubicin - pharmacokinetics ; General pharmacology ; Hydrogen-Ion Concentration ; Liposomes ; Liver - metabolism ; Male ; Medical sciences ; Particle Size ; Passive targeting ; PEG liposome ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polyethylene Glycols - administration & dosage ; Polyethylene Glycols - pharmacokinetics ; Rats ; Recombinant human serum albumin (rHSA) ; Sarcoma, Experimental - drug therapy ; Sarcoma, Experimental - metabolism ; Serum Albumin - administration & dosage ; Spleen - metabolism ; Tissue Distribution ; Tumor-bearing rats
É parte de: International journal of pharmaceutics, 2008-04, Vol.353 (1), p.28-34
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: To evaluate the effect of coupling of recombinant human serum albumin (rHSA) onto the surface of poly(ethylene glycol)-modified liposome (PEG liposome) on the in vivo disposition characteristics of liposomal doxorubicin (DXR), the pharmacokinetics and tissue distribution of DXR were evaluated after intravenous administration of rHSA-modified PEG (rHSA/PEG) liposomal DXR into tumor-bearing rats. rHSA/PEG liposome prepared using a hetero-bifunctional cross-linker, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP), efficiently encapsulated DXR (over 95%). rHSA/PEG liposomal DXR showed longer blood-circulating property than PEG liposomal DXR and the hepatic and splenic clearances of rHSA/PEG liposomal DXR were significantly smaller than those of PEG liposomal DXR. It was also demonstrated that the disposition of DXR to the heart, one of the organs for DXR-related side-effects, was significantly smaller than free DXR. Furthermore, the tumor accumulation of rHSA/PEG liposomal DXR was significantly larger than that of PEG liposomal DXR. The “therapeutic index”, a criterion for therapeutic outcome, for rHSA/PEG liposomal DXR was significantly higher than PEG liposomal DXR. These results clearly indicate that rHSA-conjugation onto the surface of PEG liposome would be a useful approach to increase the effectiveness and safety of PEG liposomal DXR.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats

Yokoe, Jun-ichi ; Sakuragi, Shiho ; Yamamoto, Kayoko ; Teragaki, Takuya ; Ogawara, Ken-ichi ; Higaki, Kazutaka ; Katayama, Naohisa ; Kai, Toshiya ; Sato, Makoto ; Kimura, Toshikiro

Amsterdam: Elsevier B.V

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