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Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention

W. Watson, Gregory ; M. Beaver, Laura ; E. Williams, David ; H. Dashwood, Roderick ; Ho, Emily

The AAPS journal, 2013-10, Vol.15 (4), p.951-961 [Periódico revisado por pares]

Boston: Springer US

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Título:
Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention
Autor: W. Watson, Gregory ; M. Beaver, Laura ; E. Williams, David ; H. Dashwood, Roderick ; Ho, Emily
Assuntos: Animals ; Apoptosis - drug effects ; Apoptosis - physiology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Epigenesis, Genetic - drug effects ; Epigenesis, Genetic - physiology ; Humans ; Male ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals - administration & dosage ; Phytochemicals - chemistry ; Phytochemicals - isolation & purification ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - prevention & control ; Review ; Review Article ; Signal Transduction - drug effects ; Signal Transduction - physiology ; Vegetables
É parte de: The AAPS journal, 2013-10, Vol.15 (4), p.951-961
Notas: Guest Editors: Ah-Ng Tony Kong and Chi Chen
Descrição: Epidemiological evidence has demonstrated a reduced risk of prostate cancer associated with cruciferous vegetable intake. Follow-up studies have attributed this protective activity to the metabolic products of glucosinolates, a class of secondary metabolites produced by crucifers. The metabolic products of glucoraphanin and glucobrassicin, sulforaphane, and indole-3-carbinol respectively, have been the subject of intense investigation by cancer researchers. Sulforaphane and indole-3-carbinol inhibit prostate cancer by both blocking initiation and suppressing prostate cancer progression in vitro and in vivo . Research has largely focused on the anti-initiation and cytoprotective effects of sulforaphane and indole-3-carbinol through induction of phases I and II detoxification pathways. With regards to suppressive activity, research has focused on the ability of sulforaphane and indole-3-carbinol to antagonize cell signaling pathways known to be dysregulated in prostate cancer. Recent investigations have characterized the ability of sulforaphane and indole-3-carbinol derivatives to modulate the activity of enzymes controlling the epigenetic status of prostate cancer cells. In this review, we will summarize the well-established, “classic” non-epigenetic targets of sulforaphane and indole-3-carbinol, and highlight more recent evidence supporting these phytochemicals as epigenetic modulators for prostate cancer chemoprevention.
Editor: Boston: Springer US
Idioma: Inglês

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Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention

W. Watson, Gregory ; M. Beaver, Laura ; E. Williams, David ; H. Dashwood, Roderick ; Ho, Emily

Boston: Springer US

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