Drug Discovery: A Historical Perspective

• Autor: Drews, Jürgen
• Assuntos: Analysis ; Biochemistry ; Biological and medical sciences ; Biotechnology ; Chemicals ; Chemicals industries ; Chemistry ; Chemistry, Pharmaceutical - history ; Combinatorial Chemistry Techniques ; Discovery and exploration ; Drug Design ; Drug discovery ; Drug Evaluation, Preclinical - history ; Drug Industry - history ; Drug Therapy ; Drugs ; General pharmacology ; genomics ; History ; History of medicine ; History, 19th Century ; History, 20th Century ; Information storage and retrieval systems ; Medical sciences ; Medical treatment ; Miscellaneous ; Molecular Biology ; Molecules ; Narcotics ; Organic Chemistry ; Pharmaceutical chemistry ; Pharmaceutical industry ; Pharmaceutical research ; Pharmacology ; Pharmacology, Clinical ; Pharmacology. Drug treatments ; Pharmacy ; Proteins ; Receptors ; Research and Development ; Reviews ; Science ; Screening Tests ; Technology Transfer ; Technology, Pharmaceutical - history
• É parte de: Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5460), p.1960-1964
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• Descrição: Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the progress of medicine during the past century than any other scientific factor. The advent of molecular biology and, in particular, of genomic sciences is having a deep impact on drug discovery. Recombinant proteins and monoclonal antibodies have greatly enriched our therapeutic armamentarium. Genome sciences, combined with bioinformatic tools, allow us to dissect the genetic basis of multifactorial diseases and to determine the most suitable points of attack for future medicines, thereby increasing the number of treatment options. The dramatic increase in the complexity of drug research is enforcing changes in the institutional basis of this interdisciplinary endeavor. The biotech industry is establishing itself as the discovery arm of the pharmaceutical industry. In bridging the gap between academia and large pharmaceutical companies, the biotech firms have been effective instruments of technology transfer.
  
• Editor: Washington, DC: American Society for the Advancement of Science
  
• Idioma: Inglês