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The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria

Zhu, Q. (University of Kentucky Medical Center, Lexington, KY.) ; Hulen, D ; Liu, T ; Clarke, M

Proceedings of the National Academy of Sciences - PNAS, 1997-07, Vol.94 (14), p.7308-7313 [Periódico revisado por pares]

United States: National Academy of Sciences of the United States of America

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Título:
The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria
Autor: Zhu, Q. (University of Kentucky Medical Center, Lexington, KY.) ; Hulen, D ; Liu, T ; Clarke, M
Assuntos: Amino Acid Sequence ; AMINO ACID SEQUENCES ; Animals ; Antiserum ; Base Sequence ; Biological Sciences ; Cell nucleus ; Cells ; Cellular biology ; CHEMICAL COMPOSITION ; CITOLOGIA ; Cloning, Molecular ; CLUA GENE ; COMPLEMENTATION ; COMPOSICION QUIMICA ; COMPOSITION CHIMIQUE ; Cytokinesis ; CYTOLOGIE ; CYTOLOGY ; DICTYOSTELIUM ; Dictyostelium - genetics ; Dictyostelium - ultrastructure ; DICTYOSTELIUM DISCOIDEUM ; DNA ; Fungal Proteins - genetics ; GENBANK/U49332 ; GENE ; GENES ; GENETICA ; GENETICS ; GENETIQUE ; MITOCHONDRIA ; Mitochondria - genetics ; Mitochondria - ultrastructure ; MITOCHONDRIE ; MITOCONDRIA ; MOLECULAR SEQUENCE DATA ; MUTACION ; MUTANT ; MUTANTES ; MUTANTS ; MUTATION ; Neurons ; NUCLEOTIDE SEQUENCE ; OPEN READING FRAMES ; Plasmids ; PROTEINAS ; PROTEINE ; PROTEINS ; Proteins - genetics ; Protozoan Proteins ; SECUENCIA NUCLEOTIDICA ; SEQUENCE NUCLEOTIDIQUE ; STRUCTURAL GENES
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1997-07, Vol.94 (14), p.7308-7313
Notas: F60
1997051514
F30
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
To whom reprint requests should be addressed at: Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, 825 N.E. 13th Street, Oklahoma City, OK 73104. e-mail: clarkem@omrf.uokhsc.edu.
James A. Spudich, Stanford University, Stanford, CA
Present address: University of Kentucky Medical Center, 800 Rose Street, Room MN523, Lexington, KY 40536-0084.
Descrição: The cluA gene of Dictyostelium discoideum encodes a novel 150-kDa protein. Disruption of cluA results in clustering of mitochondria near the cell center. This is a striking difference from normal cells, whose mitochondria are dispersed uniformly throughout the cytoplasm. The mutant cell populations also exhibit an increased frequency of multinucleated cells, suggesting an impairment in cytokinesis. Both phenotypes are reversed by transformation of cluA- cells with a plasmid carrying a constitutively expressed cluA gene. The predicted sequence of the cluA gene product is homologous to sequences encoded by open reading frames in the genomes of Saccharomyces cerevisiae and Caenorhabditis elegans, but not to any known protein. The only exception is a short region with some homology to the 42-residue imperfect repeats present in the kinesin light chain, which probably function in protein-protein interaction. These studies identify a new class of proteins that appear to be required for the proper distribution of mitochondria
Editor: United States: National Academy of Sciences of the United States of America
Idioma: Inglês

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The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria

Zhu, Q. (University of Kentucky Medical Center, Lexington, KY.) ; Hulen, D ; Liu, T ; Clarke, M

United States: National Academy of Sciences of the United States of America

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