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Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response

Trocoli Torrecilhas, Ana Claudia ; Tonelli, Renata Rosito ; Pavanelli, Wander Rogério ; da Silva, João Santana ; Schumacher, Robert Ivan ; de Souza, Wanderley ; e Silva, Narcisa Cunha ; de Almeida Abrahamsohn, Ises ; Colli, Walter ; Manso Alves, Maria Júlia

Microbes and infection, 2009, Vol.11 (1), p.29-39 [Periódico revisado por pares]

Kidlington: Elsevier SAS

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Título:
Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response
Autor: Trocoli Torrecilhas, Ana Claudia ; Tonelli, Renata Rosito ; Pavanelli, Wander Rogério ; da Silva, João Santana ; Schumacher, Robert Ivan ; de Souza, Wanderley ; e Silva, Narcisa Cunha ; de Almeida Abrahamsohn, Ises ; Colli, Walter ; Manso Alves, Maria Júlia
Assuntos: Animals ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Cell Membrane - chemistry ; Cell Membrane - immunology ; Chagas Cardiomyopathy - immunology ; Chagas Cardiomyopathy - mortality ; Chagas Cardiomyopathy - parasitology ; Chagas Cardiomyopathy - physiopathology ; Cytokines ; Female ; Fundamental and applied biological sciences. Psychology ; Glycoproteins - analysis ; Heart - parasitology ; Inflammation - immunology ; Inflammation - parasitology ; Inflammation - physiopathology ; Interleukin-10 - biosynthesis ; Interleukin-4 - biosynthesis ; Life cycle. Host-agent relationship. Pathogenesis ; Macrophages - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Myocardium - immunology ; Myocardium - pathology ; Neuraminidase - analysis ; Protozoa ; T. cruzi infectivity ; Tissue parasitism ; Trypanosoma cruzi - immunology ; Trypanosoma cruzi - pathogenicity ; Virulence
É parte de: Microbes and infection, 2009, Vol.11 (1), p.29-39
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Trypanosoma cruzi trypomastigotes continuously shed into the medium plasma membrane fragments sealed as vesicles enriched in glycoproteins of the gp85 and trans-sialidase (TS) superfamily and α-galactosyl-containing glycoconjugates. Injection of a vesicle fraction into BALB/c mice prior to T. cruzi infection led to 40% of deaths on the 16th day post-infection and 100% on day 20th whereas 20% of untreated animals survived for more than 30 days. The vesicle-treated animals developed severe heart pathology, with intense inflammatory reaction and higher number of amastigote nests. Analysis of the inflammatory infiltrates 15 days after infection showed predominance of TCD4 + lymphocytes and macrophages, but not of TCD8 + cells, as well as a decrease of areas labeled with anti-iNOS antibodies as compared to the control. Higher levels of IL-4 and IL-10 mRNAs were found in the hearts and higher IL-10 and lower NO levels in splenocytes of vesicles pretreated animals. Treatment of mice with neutralizing anti-IL-10 or anti-IL-4 antibodies precluded the effects of pre-inoculation of membrane vesicles on infection. These results indicate that T. cruzi shed membrane components increase tissue parasitism and inflammation by stimulation of IL-4 and IL-10 synthesis and thus may play a central role in the pathogenesis of Chagas’ disease acute phase.
Editor: Kidlington: Elsevier SAS
Idioma: Inglês

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Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response

Trocoli Torrecilhas, Ana Claudia ; Tonelli, Renata Rosito ; Pavanelli, Wander Rogério ; da Silva, João Santana ; Schumacher, Robert Ivan ; de Souza, Wanderley ; e Silva, Narcisa Cunha ; de Almeida Abrahamsohn, Ises ; Colli, Walter ; Manso Alves, Maria Júlia

Kidlington: Elsevier SAS

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