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Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin

MIZUNO, T. M ; KLEOPOULOS, S. P ; BERGEN, H. T ; ROBERTS, J. L ; PRIEST, C. A ; MOBBS, C. V

Diabetes (New York, N.Y.), 1998-02, Vol.47 (2), p.294-297 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
Autor: MIZUNO, T. M ; KLEOPOULOS, S. P ; BERGEN, H. T ; ROBERTS, J. L ; PRIEST, C. A ; MOBBS, C. V
Assuntos: Animals ; Biological and medical sciences ; Blotting, Northern ; Drug Resistance ; Fasting ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Hypothalamic Hormones - genetics ; Hypothalamus - metabolism ; Leptin ; Male ; Melanins - genetics ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Obese ; Neuropeptide Y - genetics ; Obesity - metabolism ; Pituitary Hormones - genetics ; Proteins - pharmacology ; RNA, Messenger - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: Diabetes (New York, N.Y.), 1998-02, Vol.47 (2), p.294-297
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Reduction in the activity of the alpha-melanocyte-stimulating hormone (alpha-MSH) system causes obesity, and infusions of alpha-MSH can produce satiety, raising the possibility that alpha-MSH may mediate physiological satiety signals. Since alpha-MSH is coded for by the pro-opiomelanocortin (POMC) gene, we examined if POMC gene expression would be inhibited by fasting in normal mice or in models of obesity characterized by leptin insufficiency (ob/ob) or leptin insensitivity (db/db). In wild-type mice, hypothalamic POMC mRNA was decreased > 60% after a 2-day fast and was positively correlated with leptin mRNA. Similarly, compared with controls, POMC mRNA was decreased by at least 60% in both db/db and ob/ob mice. POMC mRNA was negatively correlated with both neuropeptide Y (NPY) and melanin-concentrating hormone (MCH) mRNA. Finally, treatment of both male and female ob/ob mice with leptin stimulated hypothalamic POMC mRNA by about threefold. These results suggest that impairment in production, processing, or responsiveness to alpha-MSH may be a common feature of obesity and that hypothalamic POMC neurons, stimulated by leptin, may constitute a link between leptin and the melanocortin system.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin

MIZUNO, T. M ; KLEOPOULOS, S. P ; BERGEN, H. T ; ROBERTS, J. L ; PRIEST, C. A ; MOBBS, C. V

Alexandria, VA: American Diabetes Association

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