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Initiation of RPS2-Specified Disease Resistance in Arabidopsis Is Coupled to the AvrRpt2-Directed Elimination of RIN4

Axtell, Michael J. ; Staskawicz, Brian J.

Cell, 2003-02, Vol.112 (3), p.369-377 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Initiation of RPS2-Specified Disease Resistance in Arabidopsis Is Coupled to the AvrRpt2-Directed Elimination of RIN4
Autor: Axtell, Michael J. ; Staskawicz, Brian J.
Assuntos: Alleles ; Arabidopsis - genetics ; Arabidopsis - immunology ; Arabidopsis - microbiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - immunology ; Arabidopsis Proteins - metabolism ; Bacterial Infections - genetics ; Bacterial Infections - immunology ; Bacterial Proteins - genetics ; Bacterial Proteins - immunology ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Gene Expression Regulation, Plant - genetics ; Gene Expression Regulation, Plant - immunology ; Immunity, Innate - genetics ; Immunity, Innate - immunology ; Immunologic Surveillance - genetics ; Immunologic Surveillance - immunology ; Mutation - genetics ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - immunology ; Signal Transduction - genetics ; Signal Transduction - immunology
É parte de: Cell, 2003-02, Vol.112 (3), p.369-377
Notas: ObjectType-Article-2
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Descrição: Plants have evolved a sophisticated innate immune system to recognize invading pathogens and to induce a set of host defense mechanisms resulting in disease resistance. Pathogen recognition is often mediated by plant disease resistance (R) proteins that respond specifically to one or a few pathogen-derived molecules. This specificity has led to suggestions of a receptor-ligand mode of R protein function. Delivery of the bacterial effector protein AvrRpt2 by Pseudomonas syringae specifically induces disease resistance in Arabidopsis plants expressing the RPS2 R protein. We demonstrate that RPS2 physically interacts with Arabidopsis RIN4 and that AvrRpt2 causes the elimination of RIN4 during activation of the RPS2 pathway. AvrRpt2-mediated RIN4 elimination also occurs in the rps2, ndr1, and Atrar1 mutant backgrounds, demonstrating that this activity can be achieved independent of an RPS2-mediated signaling pathway. Therefore, we suggest that RPS2 initiates signaling based upon perception of RIN4 disappearance rather than direct recognition of AvrRpt2.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Initiation of RPS2-Specified Disease Resistance in Arabidopsis Is Coupled to the AvrRpt2-Directed Elimination of RIN4

Axtell, Michael J. ; Staskawicz, Brian J.

United States: Elsevier Inc

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