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In vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus

Kohn, L. K. ; Queiroga, C. L. ; Martini, M. C. ; Barata, L. E. ; Porto, P. S. S. ; Souza, L. ; Arns, C. W.

Pharmaceutical biology, 2012-10, Vol.50 (10), p.1269-1275 [Periódico revisado por pares]

England: Informa Healthcare

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Título:
In vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus
Autor: Kohn, L. K. ; Queiroga, C. L. ; Martini, M. C. ; Barata, L. E. ; Porto, P. S. S. ; Souza, L. ; Arns, C. W.
Assuntos: Animal Diseases - drug therapy ; Animal Diseases - virology ; Animals ; Antiviral ; Antiviral Agents - administration & dosage ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Brazil ; Cattle ; crude extract ; Dose-Response Relationship, Drug ; Herpesvirus 5, Bovine - drug effects ; Lauraceae - chemistry ; Maytenus - chemistry ; Medicine, Traditional ; Metapneumovirus - drug effects ; Mice ; MTT ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; plants ; Plants, Medicinal - chemistry ; sulforhodamine B ; Swine ; Virus Replication - drug effects
É parte de: Pharmaceutical biology, 2012-10, Vol.50 (10), p.1269-1275
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Context: Medicinal plants are well known for their use in traditional folk medicine as treatments for many diseases including infectious diseases. Objective: Six Brazilian medicinal plant species were subjected to an antiviral screening bioassay to investigate and evaluate their biological activities against five viruses: bovine herpesvirus type 5 (BHV-5), avian metapneumovirus (aMPV), murine hepatitis virus type 3, porcine parvovirus and bovine respiratory syncytial virus. Materials and methods: The antiviral activity was determined by a titration technique that depends on the ability of plant extract dilutions (25 or 2.5 µg/mL) to inhibit the viral induced cytopathic effect and the extracts' inhibition percentage (IP). Results: Two medicinal plant species showed potential antiviral activity. The Aniba rosaeodora Ducke (Lauraceae) extract had the best results, with 90% inhibition of viral growth at 2.5 µg/mL when the extract was added during the replication period of the aMPV infection cycle. The Maytenus ilicifolia (Schrad.) Planch. (Celastraceae) extracts at a concentration of 2.5 µg/mL exhibited antiviral activity during the attachment phase of BHV-5 (IP = 100%). Discussion and conclusion: The biomonitored fractionation of the active extracts from M. ilicifolia and A. rosaeodora could be a potential tool for identifying their active compounds and determining the exact mechanism of action.
Editor: England: Informa Healthcare
Idioma: Inglês

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In vitro antiviral activity of Brazilian plants (Maytenus ilicifolia and Aniba rosaeodora) against bovine herpesvirus type 5 and avian metapneumovirus

Kohn, L. K. ; Queiroga, C. L. ; Martini, M. C. ; Barata, L. E. ; Porto, P. S. S. ; Souza, L. ; Arns, C. W.

England: Informa Healthcare

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