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Elevated risk for HIV-1 infection in adolescents and young adults in São Paulo, Brazil

Bassichetto, Katia Cristina ; Bergamaschi, Denise Pimentel ; Oliveira, Solange Maria ; Deienno, Marylei Casteldelli Verri ; Bortolato, Reginaldo ; de Rezende, Heloíza Vilma ; Arthur, Thaís ; Tomiyama, Helena ; Watkins, Colyn ; Mesquita, Fabio ; Abbate, Maria Cristina ; Kallas, Esper Georges Nixon, Douglas

PloS one, 2008-01, Vol.3 (1), p.e1423-e1423 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Elevated risk for HIV-1 infection in adolescents and young adults in São Paulo, Brazil
Autor: Bassichetto, Katia Cristina ; Bergamaschi, Denise Pimentel ; Oliveira, Solange Maria ; Deienno, Marylei Casteldelli Verri ; Bortolato, Reginaldo ; de Rezende, Heloíza Vilma ; Arthur, Thaís ; Tomiyama, Helena ; Watkins, Colyn ; Mesquita, Fabio ; Abbate, Maria Cristina ; Kallas, Esper Georges
Nixon, Douglas
Assuntos: Acquired immune deficiency syndrome ; Adolescent ; Adolescents ; Adult ; Adults ; Age ; AIDS ; Brazil - epidemiology ; Chronic infection ; Counseling ; Disease prevention ; Disease transmission ; Drug therapy ; Epidemics ; Exposure ; Female ; Health risks ; HIV ; HIV Infections - epidemiology ; HIV-1 - isolation & purification ; Human immunodeficiency virus ; Humans ; Immunology ; Infections ; Infectious diseases ; Infectious Diseases/Epidemiology and Control of Infectious Diseases ; Infectious Diseases/HIV Infection and AIDS ; Male ; Medical laboratories ; Medical tests ; Mens health ; Middle age ; Multivariate analysis ; Public health ; Public Health and Epidemiology/Infectious Diseases ; Public Health and Epidemiology/Preventive Medicine ; Recreational use ; Risk Factors ; Seroconversion ; Sexual behavior ; Sexually transmitted diseases ; STD ; Syphilis ; Teenagers ; Young adults
É parte de: PloS one, 2008-01, Vol.3 (1), p.e1423-e1423
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: EK KB SO MV RB Hd TA HT FM MA. Performed the experiments: KB SO MV RB Hd. Analyzed the data: EK KB CW DB MV RB Hd TA HT MA. Contributed reagents/materials/analysis tools: KB. Wrote the paper: EK KB CW DB FM MA.
Descrição: Recent studies have sought to describe HIV infection and transmission characteristics around the world. Identification of early HIV-1 infection is essential to proper surveillance and description of regional transmission trends. In this study we compare people recently infected (RI) with HIV-1, as defined by Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS), to those with chronic infection. Subjects were identified from 2002-2004 at four testing sites in São Paulo. Of 485 HIV-1-positive subjects, 57 (12%) were defined as RI. Of the participants, 165 (34.0%) were aware of their serostatus at the time of HIV-1 testing. This proportion was statistically larger (p<0.001) among the individuals without recent infection (n = 158, 95.8%) compared to 7 individuals (4.2%) with recently acquired HIV-1 infection. In the univariate analysis, RI was more frequent in <25 and >59 years-old age strata (p<0.001). The majority of study participants were male (78.4%), 25 to 45 years-old (65.8%), white (63.2%), single (61.7%), with family income of four or more times the minimum wage (41.0%), but with an equally distributed educational level. Of those individuals infected with HIV-1, the predominant route of infection was sexual contact (89.4%), with both hetero (47.5%) and homosexual (34.5%) exposure. Regarding sexual activity in these individuals, 43.9% reported possible HIV-1 exposure through a seropositive partner, and 49.4% reported multiple partners, with 47% having 2 to 10 partners and 37.4% 11 or more; 53.4% of infected individuals reported condom use sometimes; 34.2% reported non-injecting, recreational drug use and 23.6% were reactive for syphilis by VDRL. Subjects younger than 25 years of age were most vulnerable according to the multivariate analysis. In this study, we evaluated RI individuals and discovered that HIV-1 has been spreading among younger individuals in São Paulo and preventive approaches should, therefore, target this age stratum.
Editor: United States: Public Library of Science
Idioma: Inglês

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Elevated risk for HIV-1 infection in adolescents and young adults in São Paulo, Brazil

United States: Public Library of Science

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