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Macrophages Keep Your Gut Moving

Lee, Chan Hee ; Kim, Min-Seon

Molecules and Cells, 2023, 46(11), , pp.672-674 [Periódico revisado por pares]

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Título:
Macrophages Keep Your Gut Moving
Autor: Lee, Chan Hee ; Kim, Min-Seon
Assuntos: Gastrointestinal Tract ; Macrophages ; 생물학
É parte de: Molecules and Cells, 2023, 46(11), , pp.672-674
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
KISTI1.1003/JNL.JAKO202310643220276
Descrição: Schematic diagram of the interaction between the intestinal muscularis externa (MMΦ) macrophages and the enteric nervous system (ENS) neurons during different developmental periods. At the early postnatal stage, MMΦs play a critical role in ENS maturation and refinement through synaptic pruning and enteric neuron phagocytosis. In addition, during the adult stage, a specific MMΦ subset named neuron-associated (NA)-MMΦ, supports enteric neuronal survival and functions. Conversely, enteric neurons promote the phenotypic MMΦ changes by secreting transforming growth factor-β (TGFβ), transitioning them from a phagocytic phenotype in the early postnatal period to a neuroprotective and immune-surveillant phenotype in the young adult period. Disruptions in these interactions could lead to alterations in the enteric neuron numbers, ultimately resulting in reduced gut motility.
Editor: United States: 한국분자세포생물학회
Idioma: Inglês;Coreano

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