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Protein Chip-based GLP-1 Receptor Assay System

박찬원 ; 강인철

BioChip Journal, 2014, 8(3), , pp.234-239 [Periódico revisado por pares]

Heidelberg: 한국바이오칩학회

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Título:
Protein Chip-based GLP-1 Receptor Assay System
Autor: 박찬원 ; 강인철
Assuntos: Agonists ; Assaying ; Biomedical Engineering and Bioengineering ; Biotechnology ; Chemical compounds ; Chemistry ; Chemistry and Materials Science ; Fluorescent dyes ; Fluorescent indicators ; Original Article ; Proteins ; Receptors ; 생물공학
É parte de: BioChip Journal, 2014, 8(3), , pp.234-239
Notas: G704-SER000001574.2014.8.3.005
Descrição: We investigated GLP-1 Receptor (GLP-1R) assay system on the basis of receptor-ligand interaction using ProteoChip. GLP-1R was immobilized on the surface of the ProteoChip and then GLP-1 peptide labeled with a Cy5-fluorescent dye was interacted with the GLP-1R array on the chip in a dose-dependent manner. Exendin-4 was tested for targeting GLP-1R to demonstrate the chip-based GLP-1R assay system. Chemical compound 6 and 45 were screened as novel agonists of GLP-1R using the GLP-1R assay system. The compound significantly inhibited GLP-1 binding to GLP-1R in a dose-dependent manner. The protein chip-based GLP-1R assay system will serve as a useful tool for screening of novel GLP-1R agonists.
Editor: Heidelberg: 한국바이오칩학회
Idioma: Coreano;Inglês

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