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Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats

Paes, Lorena ; Lima, Daniel ; Matsuura, Cristiane ; de Souza, Maria das Graças ; Cyrino, Fátima ; Barbosa, Carolina ; Ferrão, Fernanda ; Bottino, Daniel ; Bouskela, Eliete ; Farinatti, Paulo Fatouros, Ioannis G.

PloS one, 2020-02, Vol.15 (2), p.e0218228-e0218228 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats
Autor: Paes, Lorena ; Lima, Daniel ; Matsuura, Cristiane ; de Souza, Maria das Graças ; Cyrino, Fátima ; Barbosa, Carolina ; Ferrão, Fernanda ; Bottino, Daniel ; Bouskela, Eliete ; Farinatti, Paulo
Fatouros, Ioannis G.
Assuntos: Adaptation ; Aerobics ; Animals ; Antioxidants ; Antioxidants (Nutrients) ; Aorta ; Aorta - metabolism ; Arteries ; Arterioles ; Biological markers ; Biology ; Biology and Life Sciences ; Biomarkers ; Blood vessels ; Carbonyl compounds ; Carbonyls ; Catalase ; Dilatation ; EDTA ; Endothelium ; Energy expenditure ; Ethylenediaminetetraacetic acid ; Exercise ; Exercise equipment ; Exercise intensity ; Exercise Therapy - methods ; Fitness equipment ; Fitness training programs ; Glutathione ; Glutathione peroxidase ; Glutathione Peroxidase - genetics ; Glutathione Peroxidase - metabolism ; Heart Ventricles - metabolism ; Laboratory animals ; Male ; Medicine and Health Sciences ; Microscopy ; Microvasculature ; Microvessels - physiology ; Muscles ; Myocardial Ischemia - therapy ; Myocardium ; Nitric Oxide Synthase Type III - metabolism ; Oxidative Stress ; Oxygen ; Oxygen Consumption ; Oxygen uptake ; Peroxidase ; Physical Conditioning, Animal - methods ; Physical fitness ; Physical training ; Protein Carbonylation ; Psychobiology ; Rats ; Rats, Wistar ; Reactivity ; Running ; Superoxide ; Superoxide dismutase ; Superoxide Dismutase - genetics ; Superoxide Dismutase - metabolism ; Superoxides ; Thiobarbituric acid ; Training ; Treadmills ; Vasodilation ; Ventricle
É parte de: PloS one, 2020-02, Vol.15 (2), p.e0218228-e0218228
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Systemic and central cardiovascular adaptations may vary in response to chronic exercise performed with different intensities and volumes. This study compared the effects of aerobic training with different intensities but equivalent volume upon microvascular reactivity in cremaster muscle and myocardial biomarkers of oxidative stress in Wistar rats. After peak oxygen uptake (VO2peak) assessment, rats (n = 24) were assigned into three groups: moderate-intensity exercise training (MI); high-intensity exercise training (HI); sedentary control (SC). Treadmill training occurred during 4 weeks, with exercise bouts matched by the energy expenditure (3.0-3.5 Kcal). Microvascular reactivity was assessed in vivo by intravital microscopy in cremaster muscle arterioles, while biomarkers of oxidative stress and eNOS expression were quantified at left ventricle and at aorta, respectively. Similar increasing vs. sedentary control group (SC) occurred in moderate intensity training group (MI) and high-intensity training group (HI) for endothelium-dependent vasodilation (10-4M: MI: 168.7%, HI: 164.6% vs. SC: 146.6%, P = 0.0004). Superoxide dismutase (SOD) (HI: 0.13 U/mg vs. MI: 0.09 U/mg and SC: 0.06 U/mg; P = 0.02), glutathione peroxidase (GPX) (HI: 0.00038 U/mg vs. MI: 0.00034 U/mg and SC: 0.00024 U/mg; P = 0.04), and carbonyl protein content (HI: 0.04 U/mg vs. MI: 0.03 U/mg and SC: 0.01 U/mg; P = 0.003) increased only in HI. No difference across groups was detected for catalase (CAT) (P = 0.12), Thiobarbituric acid reactive substances (TBARS) (P = 0.38) or eNOS expression in aorta (P = 0.44). In conclusion, higher exercise intensity induced greater improvements in myocardium antioxidant defenses, while gains in microvascular reactivity appeared to rely more on exercise volume than intensity.
Editor: United States: Public Library of Science
Idioma: Inglês

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Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats

Paes, Lorena ; Lima, Daniel ; Matsuura, Cristiane ; de Souza, Maria das Graças ; Cyrino, Fátima ; Barbosa, Carolina ; Ferrão, Fernanda ; Bottino, Daniel ; Bouskela, Eliete ; Farinatti, Paulo Fatouros, Ioannis G.

United States: Public Library of Science

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