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Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement

Vlastra, Wieneke ; Chandrasekhar, Jaya ; García Del Blanco, Bruno ; Tchétché, Didier ; de Brito, Fabio S. ; Barbanti, Marco ; Kornowski, Ran ; Latib, Azeem ; D’Onofrio, Augusto ; Ribichini, Flavio ; Baan, Jan ; Tijssen, Jan G.P. ; Moreno, Raul ; Dumonteil, Nicolas ; Tarasoutchi, Flavio ; Sartori, Samantha ; D’Errigo, Paola ; Tarantini, Giuseppe ; Lunardi, Mattia ; Orvin, Katia ; Pagnesi, Matteo ; Berenguer, Alberto ; Modine, Thomas ; Dangas, George ; Mehran, Roxana ; Piek, Jan J. ; Delewi, Ronak

Journal of the American College of Cardiology, 2019-12, Vol.74 (22), p.2758-2767 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement
Autor: Vlastra, Wieneke ; Chandrasekhar, Jaya ; García Del Blanco, Bruno ; Tchétché, Didier ; de Brito, Fabio S. ; Barbanti, Marco ; Kornowski, Ran ; Latib, Azeem ; D’Onofrio, Augusto ; Ribichini, Flavio ; Baan, Jan ; Tijssen, Jan G.P. ; Moreno, Raul ; Dumonteil, Nicolas ; Tarasoutchi, Flavio ; Sartori, Samantha ; D’Errigo, Paola ; Tarantini, Giuseppe ; Lunardi, Mattia ; Orvin, Katia ; Pagnesi, Matteo ; Berenguer, Alberto ; Modine, Thomas ; Dangas, George ; Mehran, Roxana ; Piek, Jan J. ; Delewi, Ronak
Assuntos: Aged ; Aged, 80 and over ; Aorta ; Aortic valve ; Aortic Valve - surgery ; Aortic Valve Stenosis - surgery ; Balloon treatment ; Bleeding ; Cardiac arrhythmia ; Cardiology ; Cardiovascular disease ; Catheterization, Peripheral - methods ; Collaboration ; Europe - epidemiology ; Family medical history ; Female ; Femoral Artery ; Gender aspects ; Gender differences ; Glomerular filtration rate ; Heart attacks ; Heart valves ; Hospitals ; Humans ; Hypertension ; Implantation ; Male ; Men ; Mortality ; outcome differences over time ; Patients ; Postoperative Complications ; predictors of 30-day mortality ; Prognosis ; Prospective Studies ; Risk Assessment - methods ; Risk Factors ; Sex ; Sex differences ; Sex Distribution ; Sex Factors ; Sexes ; Stenosis ; Stroke ; Studies ; Survival Rate - trends ; Transcatheter Aortic Valve Replacement - methods ; transfemoral aortic valve implantation ; Trends ; Women
É parte de: Journal of the American College of Cardiology, 2019-12, Vol.74 (22), p.2758-2767
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
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Descrição: Transfemoral aortic valve replacement (TAVR) is a guideline-recommended treatment option for patients with severe aortic valve stenosis. Women and men present with different baseline characteristics, which may influence procedural outcomes. This study sought to evaluate differences between women and men undergoing transfemoral TAVR across the globe during the last decade. The CENTER (Cerebrovascular EveNts in patients undergoing TranscathetER aortic valve implantation with balloon-expandable valves versus self-expandable valves)-collaboration was a global patient level dataset of patients undergoing transfemoral TAVR (N = 12,381) from 2007 to 2018. In this retrospective analysis, the study examined differences in baseline patient characteristics, 30-day stroke and mortality, and in-hospital outcomes between female and male patients. The study also assessed for temporal changes in outcomes and predictors for mortality per sex. We included 58% (n = 7,120) female and 42% (n = 5,261) male patients. Women had higher prevalence of hypertension and glomerular filtration rate <30 ml/min/1.73 m2 but lower prevalence of all other traditional cardiovascular comorbidities. Both sexes had similar rates of 30-day stroke (2.3% vs. 2.5%; p = 0.53) and mortality (5.9% vs. 5.5%; p = 0.17). In contrast, women had a 50% higher risk of life-threatening or major bleeding (6.7% vs. 4.4%; p < 0.01). Over the study period, mortality rates decreased to a greater extent in men than in women (60% vs. 50% reduction; both p < 0.001), with no reductions in stroke rates over time. In this global collaboration, women and men had similar rates of 30-day mortality and stroke. However, women had higher rates of procedural life-threatening or major bleeding after TAVR. Between 2007 and 2018, mortality rates decreased to a greater extent in men than in women. [Display omitted]
Editor: United States: Elsevier Inc
Idioma: Inglês

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Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement

United States: Elsevier Inc

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