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Immune infiltration in human tumors: a prognostic factor that should not be ignored

PAGES, F ; GALON, J ; DIEU-NOSJEAN, M.-C ; TARTOUR, E ; SAUTES-FRIDMAN, C ; FRIDMAN, W.-H

Oncogene, 2010-02, Vol.29 (8), p.1093-1102 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
Immune infiltration in human tumors: a prognostic factor that should not be ignored
Autor: PAGES, F ; GALON, J ; DIEU-NOSJEAN, M.-C ; TARTOUR, E ; SAUTES-FRIDMAN, C ; FRIDMAN, W.-H
Assuntos: Animal models ; Animals ; Biological and medical sciences ; Breast Neoplasms - diagnosis ; Care and treatment ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - physiopathology ; Cytotoxicity ; Dendritic cells ; Extravasation ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic aspects ; Genetics ; Germinal centers ; Humans ; Immune response ; Immunological memory ; Immunology ; Infiltration ; Inflammation ; Lymphatic Metastasis - diagnosis ; Lymphocytes B ; Lymphocytes T ; Macrophages ; Mast cells ; Medical sciences ; Memory cells ; Metastases ; Metastasis ; Microenvironments ; Molecular and cellular biology ; Neoplasm Staging ; Oncology ; Physiological aspects ; Prognosis ; Signal transduction ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; T cells ; Tumor cells ; Tumors
É parte de: Oncogene, 2010-02, Vol.29 (8), p.1093-1102
Notas: ObjectType-Article-1
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Descrição: The natural history of a tumor includes phases of 'in situ' growth, invasion, extravasation and metastasis. During these phases, tumor cells interact with their microenvironment and are influenced by signals coming from stromal, endothelial, inflammatory and immune cells. Indeed, tumors are often infiltrated by various numbers of lymphocytes, macrophages or mast cells. It is generally believed that the latter produce factors that maintain chronic inflammation and promote tumor growth, whereas lymphocytes may control cancer outcome, as evidenced in mouse models. In this study, we analyze data from large cohorts of human tumors, clearly establishing that infiltration of the primary tumor by memory T cells, particularly of the Th1 and cytotoxic types, is the strongest prognostic factor in terms of freedom from disease and overall survival at all stages of clinical disease. We review data suggesting that tertiary lymphoid structures adjacent to tumors and composed of mature dendritic cells (T and B cells organized as germinal centers) may be the site of an antitumor reaction. We propose an immune scoring based on the type, density and location of lymphocyte infiltrates as a novel prognostic factor for use in addition to tumor node metastasis staging to predict disease-free survival and to aid in decisions regarding adjuvant therapies in early stage human cancers.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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Immune infiltration in human tumors: a prognostic factor that should not be ignored

PAGES, F ; GALON, J ; DIEU-NOSJEAN, M.-C ; TARTOUR, E ; SAUTES-FRIDMAN, C ; FRIDMAN, W.-H

Basingstoke: Nature Publishing Group

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