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Efficient Semi-Synthesis of Natural δ‑(R)‑Tocotrienols from a Renewable Vegetal Source

Ville, Alexia ; Viault, Guillaume ; Hélesbeux, Jean-Jacques ; Guilet, David ; Richomme, Pascal ; Séraphin, Denis

Journal of natural products (Washington, D.C.), 2019-01, Vol.82 (1), p.51-58 [Periódico revisado por pares]

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Título:
Efficient Semi-Synthesis of Natural δ‑(R)‑Tocotrienols from a Renewable Vegetal Source
Autor: Ville, Alexia ; Viault, Guillaume ; Hélesbeux, Jean-Jacques ; Guilet, David ; Richomme, Pascal ; Séraphin, Denis
Assuntos: Chemical Sciences ; Garcinia - metabolism ; Organic chemistry ; Tocotrienols - isolation & purification ; Tocotrienols - metabolism
É parte de: Journal of natural products (Washington, D.C.), 2019-01, Vol.82 (1), p.51-58
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Recent studies have highlighted the biological potential of tocotrienols, a vitamin E subfamily. The major natural sources of tocotrienols are complex mixtures requiring particularly challenging purification processes. The present study describes efficient semi-synthetic strategies toward relevant δ-(R)-tocotrienol derivatives, using as a starting material δ-(R)-garcinoic acid, the major vitamin E derivative isolated from Garcinia kola nuts, a renewable vegetal source.
Editor: United States: American Chemical Society and American Society of Pharmacognosy
Idioma: Inglês

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