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Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19

Kuley, Runa ; Duvvuri, Bhargavi ; Wallin, Jeffrey J. ; Bui, Nam ; Adona, Mary Vic ; O'Connor, Nicholas G. ; Sahi, Sharon K. ; Stanaway, Ian B. ; Wurfel, Mark M. ; Morrell, Eric D. ; Liles, W. Conrad ; Bhatraju, Pavan K. ; Lood, Christian

Virulence, 2023-12, Vol.14 (1), p.2218077-2218077 [Periódico revisado por pares]

United States: Taylor & Francis

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Título:
Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19
Autor: Kuley, Runa ; Duvvuri, Bhargavi ; Wallin, Jeffrey J. ; Bui, Nam ; Adona, Mary Vic ; O'Connor, Nicholas G. ; Sahi, Sharon K. ; Stanaway, Ian B. ; Wurfel, Mark M. ; Morrell, Eric D. ; Liles, W. Conrad ; Bhatraju, Pavan K. ; Lood, Christian
Assuntos: clinical biomarkers ; COVID-19 ; Humans ; Leukocyte L1 Antigen Complex ; Methionine ; mitochondrial peptides ; N-formyl methionine peptide ; N-Formylmethionine - pharmacology ; Neutrophil Activation ; Neutrophils ; Peptides ; Racemethionine ; Research Paper ; systemic inflammation
É parte de: Virulence, 2023-12, Vol.14 (1), p.2218077-2218077
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally
Descrição: Neutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if N-formyl methionine (fMet) contributes to neutrophil activation in COVID-19. Elevated levels of calprotectin, neutrophil extracellular traps (NETs) and fMet were observed in COVID-19 patients (n = 68), particularly in critically ill patients, as compared to HC (n = 19, p < 0.0001). Of note, the levels of NETs were higher in ICU patients with COVID-19 than in ICU patients without COVID-19 (p < 0.05), suggesting a prominent contribution of NETs in COVID-19. Additionally, plasma from COVID-19 patients with mild and moderate/severe symptoms induced in vitro neutrophil activation through fMet/FPR1 (formyl peptide receptor-1) dependent mechanisms (p < 0.0001). fMet levels correlated with calprotectin levels validating fMet-mediated neutrophil activation in COVID-19 patients (r = 0.60, p = 0.0007). Our data indicate that fMet is an important factor contributing to neutrophil activation in COVID-19 disease and may represent a potential target for therapeutic intervention.
Editor: United States: Taylor & Francis
Idioma: Inglês

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Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19

Kuley, Runa ; Duvvuri, Bhargavi ; Wallin, Jeffrey J. ; Bui, Nam ; Adona, Mary Vic ; O'Connor, Nicholas G. ; Sahi, Sharon K. ; Stanaway, Ian B. ; Wurfel, Mark M. ; Morrell, Eric D. ; Liles, W. Conrad ; Bhatraju, Pavan K. ; Lood, Christian

United States: Taylor & Francis

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